Heat shock proteins (HSPs) are a class of functionally related proteins that are involved in the folding and unfolding of other proteins. HSPs are a group of proteins that are produced in response to heat shock. When cells are subjected to high temperatures or other stresses, HSP expression rises. This increase in expression is controlled by transcription. Heat shock factor (HSF) is primarily responsible for the dramatic upregulation of the heat shock proteins, which is a crucial component of the heat shock response. Nearly every living thing, from bacteria to people, contains HSPs. Heat shock proteins seem to play a big part in the cardiovascular system. There have been reports of the roles of Hsp90, Hsp84, Hsp70, Hsp27, Hsp20, and alpha B crystallin in the cardiovasculature.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V51968 | HSP90-IN-19 | 2927442-48-4 | HSP90-IN-19 is a potent heat shock protein 90 (Hsp90) inhibitor. |
|
V55774 | HSP90-IN-20 | 747414-31-9 | HSP90-IN-20 (compound 78p) is a potent HSP90 inhibitor (antagonist) with IC50 of ≤10 μM. |
|
V55778 | HSP90-IN-22 | 442898-75-1 | HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor (antagonist) with antiproliferation properties on cells, with IC50s of 3.65 μM and 2.71 μM for MCF7 breast cancer cells and SKBr3 breast cancer cells, respectively. |
|
V79408 | HSP90-IN-23 | HSP90-IN-23 (Comp 12-1) is an inhibitor (blocker/antagonist) of heat shock protein 90 (HSP90) with IC50 of 9 nM. | |
|
V80314 | HSP90-IN-25 | HSP90-IN-25 (compound 4a) is an HSP90 inhibitor that specifically inhibits the ATPase activity of HSP90. | |
|
V53407 | Icapamespib (PU-HZ151) | 1000999-96-1 | Icapamespib (PU-HZ151) is a potent HSP90 inhibitor (antagonist) with EC50 of 5 nM. |
|
V55771 | JG-258 | 2241517-83-7 | JG-258 is an inactive negative control (NC) of an Hsp70 inhibitor. |
|
V55779 | KNK423 | 1859-42-3 | KNK423 is a specific inhibitor of heat shock protein (HSP) synthesis. |
|
V51816 | MAO A/HSP90-IN-1 | 2927489-95-8 | MAO A/HSP90-IN-1 (4-b) is a MAO A/HSP90 dual (bifunctional) inhibitor (antagonist) with IC50 of 1.77 μM in glioblastoma GL26 cells and IC50 of 0.019 μM for HSP90α. |
|
V51815 | MAO A/HSP90-IN-2 | 2927489-99-2 | MAO A/HSP90-IN-2 (compound 4-C) is a dual (bifunctional) inhibitor of HSP90 and MAO A, with IC50s of 0.016 and 4.58 μM respectively. |
|
V2243 | MB-10 | 394694-98-5 | MB-10, also known as MitoBloCK-10, is a novel, potent and first-in-class small molecule modulator that can attenuate the activity of protein-associated motor (PAM) complex. |
|
V55777 | MPC-0767 | 1310540-32-9 | MPC-0767 is a specific, orally administered hsp90 inhibitor. |
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V80922 | NDNA3 | NDNA3 (compound 14) is a selective inhibitor of Hsp90α (IC50= 0.51 μM). | |
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V78107 | NDNA4 | NDNA4 (compound 17) is a selective inhibitor of Hsp90α (IC50= 0.34 μM). | |
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V55776 | Palmitic acid-1,2,3,4-13C4 (palmitic acid 13C4) | 287100-89-4 | Palmitic acid-1,2,3,4-13C4 is a 13C (carbon 13)-labeled Palmitic acid. |
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V52945 | Palmitic acid-1-13C (palmitic acid 1-13C) | 57677-53-9 | Palmitic acid-1-13C is a 13C (carbon 13)-labeled Palmitic acid. |
|
V53350 | Palmitic acid-13C (palmitic acid 13C) | 287100-87-2 | Palmitic acid-13C is a 13C (carbon 13)-labeled Palmitic acid. |
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V55772 | Palmitic acid-13C sodium | 201612-54-6 | Palmitic acid-13C (sodium) is a 13C (carbon 13)-labeled Palmitic acid sodium. |
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V55766 | Palmitic acid-13C16 sodium | 2483736-17-8 | Palmitic acid-13C16 (sodium) is a 13C (carbon 13)-labeled Palmitic acid sodium. |
|
V55769 | Palmitic acid-13C2 (palmitic acid 13C2) | 86683-25-2 | Palmitic acid-13C2 is a 13C (carbon 13)-labeled Palmitic acid. |
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