Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine.The trypsin family and the subtilisin family are two families that have received particular attention in research. The process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing are just a few of the numerous cellular and extracellular functions that serine proteases are essential for. A threonine residue is present in the active site of a family of proteolytic enzymes known as thronine (Thr) proteases. Although the catalytic subunits of the proteasome are the prototype members of this class of enzymes, the active site geometry and mechanism of acyltransferases were convergently evolved.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V114711 | (E)-FOBISIN101 | 1370281-06-3 | (E)-FOBISIN101 is a 14-3-3 protein inhibitor (14-3-3γ IC50 = 16.4 μM; 14-3-3ζ IC50 = 9.3 μM). |
|
V111233 | (Z-AR)2Rh110 | 88064-36-2 | (Z-AR)2Rh110 is a rhodamine derivative. |
|
V117276 | 2-thioacetyl MAGE | 112014-15-0 | 2-Thioacetyl MAGE is a colorimetric substrate for serine hydrolase KIAA1363. |
|
V0711 | AEBSF HCl | 30827-99-7 | AEBSF HCl (known also as AEBSF Hydrochloride) is a novel, broad spectrum, covalently/irreversible inhibitor of serine protease including trypsin, chymotrypsin, plasmin and thrombin. |
|
V111897 | 4-Iodobenzylamine hydrochloride | 59528-27-7 | 4-Iodobenzylamine hydrochloride ((4-iodophenyl)methylamine hydrochloride) is a probe that can detect the binding patterns of serine proteases such as trypsin and urokinase-type plasminogen activator (uPA). |
|
V111712 | Abz-AFRFSQ-EDDnp | 1926163-28-1 | Abz-AFRFSQ-EDDnp is a human kallikrein 6 substrate (Kcat/Km = 38667 s⁻1 mM⁻1). |
|
V116077 | Ac-KQKLR-AMC TFA | 2237216-84-9 | Ac-KQKLR-AMC TFA is a cathepsin S substrate peptide labeled with AMC fluorescence (excitation/emission wavelength = 354 nm/442 nm). |
|
V113207 | Boc-Ala-Gly-Pro-Arg-AMC | 118850-78-5 | Boc-Ala-Gly-Pro-Arg-AMC is a synthetic fluorescent substrate widely used for detecting protease activity. |
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V111264 | Cbz-QFR-kbt | 3086979-57-6 | Cbz-QFR-kbt is a ketobenzothiazoline TMPRSS2 inhibitor with an IC50 value of 0.42 nM. |
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V114428 | Cetyl tranexamate hydrochloride | 913541-96-5 | Cetyl tranexamic acid salt (TXC) is an esterified derivative of tranexamic acid. |
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V117259 | Chicken Ovomucoid | Chicken ovomucoid is one of the main components of chicken ovalbumin and has trypsin inhibitory activity and thermal stability. | |
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V116661 | DCLK1-IN-6 | DCLK1-IN-6 (compound 12n) is a dual corticosteroid-like kinase 1 (DCLK1) inhibitor with an IC50 value of 58 nM. | |
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V115670 | MD5 | 3051556-89-6 | MD5 is a selective TMPRSS6 mimic peptide inhibitor with an IC50 of 22 nM and a Ki of 3.4 nM against recombinant human TMPRSS6 protein. |
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V115389 | MOL-6131 | 583868-50-2 | MOL-6131 is a highly selective, reversible trypsin inhibitor with a Ki value of 45 nM. |
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V118260 | Oscillamide Y | 168482-80-2 | Oscillatamide Y (compound 1) is a urea-containing cyclic peptide and a chymotrypsin inhibitor. |
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V117246 | Oscillamide Y TFA | Oscillamide Y TFA is the trifluoroacetate of Oscillamide Y. | |
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V113289 | PAI-1 | 139446-70-1 | PAI-1 is a plasminogen activator inhibitor. |
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V119077 | Poly(ethylene terephthalate) hydrolase | Polyethylene terephthalate hydrolase is an enzyme that participates in the decomposition of polyethylene terephthalate (PET), one of the most common types of waste plastics. | |
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V119083 | Protein phosphatase 2C | Protein phosphatase 2C is a serine/threonine phosphatase that dephosphorylates key proteins in the cell death pathway. | |
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V119679 | REGN7999 | REGN7999 is a monoclonal antibody that inhibits TMPRSS6. |
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