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    AEBSF HCl
    AEBSF HCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0711
    CAS #: 30827-99-7Purity ≥98%

    Description: AEBSF HCl (known also as AEBSF Hydrochloride) is a novel, broad spectrum, covalently/irreversible inhibitor of serine protease including trypsin, chymotrypsin, plasmin and thrombin. AEBSF was found to inhibit Aβ production in various cell lines. In K293 cells transfected with APP695 (K695sw), AEBSF showed does-dependent reduction of Aβ with IC50 value of about 1mM. In HS695 and SKN695 cells transfected with wild-type APP695, AEBSF showed inhibition effect with IC50 value of about 300 μM.

    References: J Leukoc Biol. 1996 Sep;60(3):328-36; J Antimicrob Chemother. 2002 May;49(5):871-4; Contraception. 2011 Dec;84(6):642-8.

    Related CAS #: 30827-99-7 (HCl); 34284-75-8 (free base)

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    Molecular Weight (MW)239.69
    FormulaC8H11ClFNO2S
    CAS No.30827-99-7
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 47 mg/mL (196.1 mM)
    Water: 20 mg/mL (83.4 mM)
    Ethanol: 47 mg/mL (196.1 mM)
    Other info

    Chemical Name: 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride

    InChi Key: WRDABNWSWOHGMS-UHFFFAOYSA-N

    InChi Code: InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H

    SMILES Code: O=S(C1=CC=C(CCN)C=C1)(F)=O.[H]Cl

    Synonyms

    AEBSF HCl; AEBSF hydrochloride; 


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    In Vitro

    In vitro activity: AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern


    Cell Assay: AEBSF was found to inhibit Aβ production in various cell lines. In K293 cells transfected with βAPP695 (K695sw), AEBSF showed dose-dependent reduction of Aβ with the IC50 value of about 1 mM. In HS695 and SKN695 cells transfected with wild-type APP695, AEBSF showed inhibition effect with IC50 value of about 300 μM. AEBSF was also found to increase α-cleavege and inhibit β- cleavage.

    In VivoAEBSF (76.8 mg/kg daily i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model.
    Animal modelMice infected by a lethal T. Gondii
    Formulation & DosageFormulated in 0.89% saline; 76.8 mg/kg daily; i.p. injection
    References

    J Leukoc Biol. 1996 Sep;60(3):328-36; J Antimicrob Chemother. 2002 May;49(5):871-4; Contraception. 2011 Dec;84(6):642-8.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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