HCV Protease

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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HCV Protease

HCV NS3-4A serine protease is a complex composed of NS3 and its cofactor NS4A.It is crucial for processing viral polyproteins, RNA replication, and virion formation and contains serine protease and NTPase/RNA helicase activities.

The HCV NS3/4A protease effectively cleaves and inactivates two key signaling molecules, mitochondrial antiviral signaling protein (MAVS) and Toll-IL-1 receptor domain-containing adaptor inducing IFN- (TRIF), in the sensory pathways that respond to HCV pathogen-associated molecular patterns (PAMPs) to induce interferons (IFNs). Chronic liver disease such as hepatic steatosis, fibrosis, cirrhosis, and hepatocellular carcinoma are all linked to HCV infection. One of the most appealing targets for the creation of specific antiviral agents against HCV has been the NS3-4A serine protease.

HCV Protease related products

Cat No.	Product Name	CAS No.	Product Description
V3663	PSI-6206	863329-66-2	PSI-6206 (also known asGS331007 and RO-2433), a deaminated derivative of PSI-6130, is a novel, potent and selective inhibitor of HCV NS5B polymerase.
V22361	HZ-1157	1009734-33-1	HZ-1157 can inhibit HCV (hepatitis C virus) NS3/4A protease with IC50 of 1.0 μmol/L.
V98443	Ac-DEMEEC-OH	208921-05-5	Ac-DEMEEC-OH is a competitive inhibitor of HCV NS3 protease (Ki: 0.6 µM).
V115985	AV-4025 hydrochloride	1380290-35-6	AV-4025 hydrochloride (compound 13a) is an orally effective NS5A inhibitor.
V116295	BMS 605339	630417-82-2	BMS 605339 is a linear tetrapeptide α-ketoamide HCV NS3 protease inhibitor.
V94268	Faldaprevir sodium	1215856-44-2	Fadapvir sodium is an orally active, selective, non-covalent inhibitor of the NS3/4A protease of hepatitis C virus (HCV) genotypes 1a and 1b with Ki values of 2.6 and 2.0 nM, respectively.
V112019	Furaprevir	1435923-88-8	Furapuvir is a potent and selective HCV NS3/4A protease inhibitor.
V117955	HCV-IN-50	303776-85-4	HCV-IN-50 (compound 2) is a competitive and selective HCV NS5B RNA-dependent RNA polymerase inhibitor.
V116050	IDX-320	1251165-81-7	IDX-320 is a derivative of piperidine acid.
V116300	MK 6325	1263814-52-3	MK 6325 is an HCV NS3/4a protease inhibitor.
V115731	MK-2748	1193902-95-2	MK-2748 is a hepatitis C virus (HCV) NS3/4a protease inhibitor.
V80973	NS5A-IN-1		NS5A-IN-1 is a precursor of the hepatitis C virus NS5A inhibitor Pibrentasvir (ABT-530).
V73168	NS5A-IN-2	2764786-74-3	NS5A-IN-2 (Compound 33) is a potent NS5A inhibitor.
V73169	NS5A-IN-3	2764786-56-1	NS5A-IN-3 (Compound 15) is a potent NS5A inhibitor.
V0727	Danoprevir ( ITMN191, R7227; RO5190591; RG7227)	850876-88-9	Danoprevir (formerly ITMN-191, R-7227; RO-5190591; RG 7227; RG-7227; trade name Ganovo) is an orally bioavailable and15-membered macrocyclic peptidomimetic inhibitor of the NS3/4A protease of hepatitis C virus (HCV) with IC50s in the range of 0.2-3.5 nM.
V3915	VOXILAPREVIR	1535212-07-7	Voxilaprevir (formerly GS-9857; GS9857;trade name:Vosevi) is a hepatitis C virus nonstructural protein (HCV NS) 3/4A protease inhibitor developed by Gilead and approved in 2017 as an anti-HCV drug for use in combination with sofosbuvir and velpatasvir.
V3702	Elbasvir	1370468-36-2	Elbasvir (formerly known as MK-8742; MK8742; trade name Zepatier) is a potent NS5A (nonstructural protein 5A) inhibitor with anti-HCV (hepatitis C virus) activities against different HCV genotypes.
V3914	PIBRENTASVIR	1353900-92-1	Pibrentasvir (formerly ABT-530; ABT530, A-1325912; A1325912; trade name: Mavyret; Maviret), an HCV NS5A protease inhibitor, is an approved antiviral (anti-HCV) drug developed by Abbvie for treating HCV infections.
V0073	Ombitasvir (ABT267; Viekira Pak)	1258226-87-7	Ombitasvir (trade name; Viekira Pak; formerly known as ABT-267) is a novel and potent N-phenylpyrrolidine-based inhibitor of hepatitis C virus (HCV) NS5A with excellent potency, metabolic stability, and pharmacokinetics/PK.
V2976	Paritaprevir	1216941-48-8	Paritaprevir (formerly ABT-450; ABT450;Veruprevir; Viekirax;Viekira Pak; Technivie) is an acylsulfonamide analog and a component of the anti-HCV drug combination therapies: Viekira Pak (Paritaprevir+ombitasvir, ritonavir and dasabuvir) and Technivie (Paritaprevir+ombitasvir and ritonavir).