Size | Price | Stock | Qty |
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2mg |
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5mg |
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10mg |
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25mg |
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50mg |
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Other Sizes |
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Purity: ≥98%
Voxilaprevir (formerly GS-9857; GS9857; trade name: Vosevi) is a hepatitis C virus nonstructural protein (HCV NS) 3/4A protease inhibitor developed by Gilead and approved in 2017 as an anti-HCV drug for use in combination with sofosbuvir and velpatasvir.
Targets |
Hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease
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ln Vitro |
For the HCV encoded polyprotein (intomature forms of NS3, NS4A, NS4B, NS5A, and NS5B proteins) to be cleaved by protease and subsequently for viral replication, NS3/4A protease is required[1].
utilizing isogenic NS4A peptide cofactors supplied in trans and recombinant NS3 protease domains in enzymatic assays. Voxilaprevir has Ki values of 0.038 nM and 0.066 nM, respectively, against the NS3 proteases of HCV genotypes 1b and 3a[1].in stable cell lines that express HCV replicons that encode renilla luciferase (Huh-7-Lunet or Huh7-1C cells). Across genotypes 1 through 6, vitilaprevir demonstrates strong pangenotypic antiviral activity, with an EC50 ranging from 0.33 to 6.6 nM. Voxilaprevir has IC50 values of 0.33 nM, 3.9 nM, 3.3 nM, 3.7 nM, 4.5 nM, 1.8 nM, and 6.6 nM, 1.9 nM against HCV replicon strains DQ314805, H77, Con1, JFH-1, J6, J8 (full length), and HM568433, SA13 (NS3 Chimera), respectively[1].
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References |
Molecular Formula |
C40H52F4N6O9S
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Molecular Weight |
868.94
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Exact Mass |
868.35
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Elemental Analysis |
C, 55.29; H, 6.03; F, 8.75; N, 9.67; O, 16.57; S, 3.69
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CAS # |
1535212-07-7
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Related CAS # |
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Appearance |
Solid powder
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SMILES |
COC(C=C1)=CC2=C1N=C(C(O[C@@H](C3)[C@@H](CC)[C@@H](C(N[C@]4(C(NS(=O)(C5(C)CC5)=O)=O)C[C@H]4C(F)F)=O)N3C6=O)=N2)C(F)(F)CCCC[C@H]7[C@@H](C7)OC(N[C@H]6C(C)(C)C)=O
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InChi Key |
MZBLZLWXUBZHSL-FZNJKFJKSA-N
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InChi Code |
InChI=1S/C40H52F4N6O9S/c1-7-22-27-19-50(28(22)32(51)48-39(18-23(39)31(41)42)35(53)49-60(55,56)38(5)14-15-38)34(52)30(37(2,3)4)47-36(54)59-26-16-20(26)10-8-9-13-40(43,44)29-33(58-27)46-25-17-21(57-6)11-12-24(25)45-29/h11-12,17,20,22-23,26-28,30-31H,7-10,13-16,18-19H2,1-6H3,(H,47,54)(H,48,51)(H,49,53)/t20-,22-,23+,26-,27+,28+,30-,39-/m1/s1
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Chemical Name |
(33R,34S,35S,91R,92R,5S)-5-(tert-butyl)-N-((1R,2R)-2-(difluoromethyl)-1-(((1-methylcyclopropyl) sulfonyl)carbamoyl)cyclopropyl)-34-ethyl-14,14-difluoro-17-methoxy-4,7-dioxo-2,8-dioxa-6-aza-1(2,3)-quinoxalina-3(3,1)-pyrrolidina-9(1,2)-cyclopropanacyclotetradecaphane-35-carboxamide
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Synonyms |
GS-9857; GS 9857; GS9857; trade name: Vosevi
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~115.08 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (2.88 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.1508 mL | 5.7541 mL | 11.5083 mL | |
5 mM | 0.2302 mL | 1.1508 mL | 2.3017 mL | |
10 mM | 0.1151 mL | 0.5754 mL | 1.1508 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.