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NF-κB

NF-κB

Nuclear factor-κB (NF-κB)/Rel proteins include NF-κB2 p52/p100, NF-κB1 p50/p105, c-Rel, RelA/p65, and RelB.These proteins perform as two-component transcription factors that control gene expression and have an impact on a variety of biological processes, such as innate and acquired immunity, inflammation, stress responses, B-cell development, and lymphoid organogenesis.The immune system's reaction to infection is significantly regulated by NF-B. In addition, the etiology of chronic inflammatory illnesses such inflammatory bowel disease, rheumatoid arthritis, and asthma is influenced by the activation of the NF-B pathway. Septic shock, autoimmune and inflammatory disorders, viral infections, and poor immunological development have all been connected to faulty NF-B regulation.

NF-κB related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Rocaglamide V116958 (+)-Rocaglamide 1699754-37-4 (+)-Rocargageramine is the dextrorotatory enantiomer of rocargageramine.
(+)-白花前胡甲素 V29488 (+)-Praeruptorin A 73069-27-9 Praeruptorin A [(9S,10S) isomer]is a naturally occurring coumarin derivative isolated from P.
(-)-杏黄罂粟碱 V17916 (-)-Armepavine 524-20-9 Armepavine is a bioactive compound from Nelumbo nucifera.
(2E)-4-Hydroperoxy-2-nonenal V84327 (2E)-4-Hydroperoxy-2-nonenal 7439-43-2
(3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside V116618 (3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside 408324-05-0 (3R,5R)-3,5-dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane-3-O-β-D-glucopyranoside is a diarylheptane glycoside isolated from konjac (Tacca plantaginea).
(E)-2-Hydroxycinnamaldehyde (3-(2-Hydroxyphenyl)-2-propenal) V83630 (E)-2-Hydroxycinnamaldehyde (3-(2-Hydroxyphenyl)-2-propenal) 60125-23-7
(E/Z)-Sinigrin free base V108144 (E/Z)-Sinigrin free base 534-69-0 (E/Z)-glucosinolate ((E/Z)-allyl-glucuronide; (E/Z)-2-propenyl-glucuronide) free base is an orally effective aliphatic glucosinolate antileukemic compound.
(S,R,S)-AHPC-C6-NH2 dihydrochloride (VH032-C6-NH2 dihydrochloride) V82259 (S,R,S)-AHPC-C6-NH2 dihydrochloride (VH032-C6-NH2 dihydrochloride) 2341796-77-6 (S,R,S)-AHPC-C6-NH2 di-HCl (VH032-C6-NH2 di-HCl) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligand based on VH032 and 1 linker.
(S,R,S)-AHPC-C8-NH2 dihydrochloride (VH032-C8-NH2 dihydrochloride) V82258 (S,R,S)-AHPC-C8-NH2 dihydrochloride (VH032-C8-NH2 dihydrochloride) 2341796-80-1 (S,R,S)-AHPC-C8-NH2 di-HCl (VH032-C8-NH2 di-HCl) is a synthetic E3 ligase (e.g. CRBN) ligand-linker conjugate containing VHL ligand based on VH032 and 1 linker.
(Z)-11,12-Epoxyeicosatrienoic acid V109002 (Z)-11,12-Epoxyeicosatrienoic acid 200960-01-6 (Z)-11,12-epoxyeicosatotrienoic acid is a potent vasodilator for small renal arteries and has anti-inflammatory activity.
(±)-α-硫辛酸 V33981 (±)-α-Lipoic acid (Thioctic acid) 1077-28-7 α-Lipoic Acid (Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid) is a novel organosulfur compound which acts as an antioxidant, and is an essential cofactor of mitochondrial enzyme complexes.
1-Methylxanthine-13C4,15N3 (1-Methylxanthine 13C4,15N3) V82295 1-Methylxanthine-13C4,15N3 (1-Methylxanthine 13C4,15N3) 1173018-69-3 1-Methylxanthine-13C4,15N3 is a 13C- and 15N (Nitrogen 15)-labelled 1-Methylxanthine.
11-酮基乳香酸 V32342 11-Keto-beta-boswellic acid 17019-92-0 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid), a pentacyclic triterpenic acid of the oleogum resin, is a natural product isolated from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense.
2'-Deoxyuridine-13C,15N2 (2'-Deoxyuridine-13C,15N2) V82263 2'-Deoxyuridine-13C,15N2 (2'-Deoxyuridine-13C,15N2) 369656-76-8 2'-Deoxyuridine-13C,15N2 is 13C (carbon 13) and 15N (nitrogen 15) labelled 2'-Deoxyuridine.
2'-Deoxyuridine-d2-1 (2'-Deoxyuridine-d2-1) V82265 2'-Deoxyuridine-d2-1 (2'-Deoxyuridine-d2-1) 40632-23-3 2'-Deoxyuridine-d2-1 is the deuterated form of 2'-Deoxyuridine.
2'-O-Methylcytidine-d3 V82270 2'-O-Methylcytidine-d3 2653209-08-4 2'-O-Methylcytidine-d3 is deuterium labelled 2'-O-Methylcytidine.
24-O-Acetyllycoclavanol V108276 24-O-Acetyllycoclavanol 13956-53-1 24-O-acetylpineol (compound 1) is a triterpenoid anti-inflammatory agent that selectively targets the NF-κB and ERK1/2 signaling pathways.
3'-唾液乳糖钠盐 V41229 3-Sialyllactose sodium 128596-80-5 3'-Sialyllactose (3'-SL) sodium is a prebiotic that maintains immune homeostasis and exerts anti~inflammatory and anti-arthritic effects.
3-吲哚甲醇 V1995 Indole-3-carbinol (I3C) 700-06-1 Indole-3-carbinol (I3C; 3-Indolemethanol) is natural product produced by the breakdown of the glucosinolate glucobrassicin, which can be found at relatively high levels in cruciferous vegetables.
7(S)-Maresin 1 V83642 7(S)-Maresin 1 1268720-66-6
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