The PIM kinase, also known as serine/threonine kinase, is present in three distinct isoforms, namely PIM-1, PIM-2, and PIM-3. It is a key player in the biology of cancer. Pim kinases are primarily in charge of controlling the cell cycle, antiapoptotic activity, and receptor tyrosine kinase homing and migration via the JAK/STAT pathway.
Pim kinases control the activation of signaling pathways that are crucial for tumor cell proliferation, survival, and expression of drug efflux proteins. They are overexpressed in a variety of tumor types. Pim kinases are therefore desirable targets for the creation of anti-cancer chemotherapeutic drugs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2738 | (1S,3R,5R)-PIM447 dihydrochloride | 1S,3R,5R)-PIM447 dihydrochloride a potentPIMinhibitor extracted withIC50values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3. | |
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V0441 | (Z)-SMI-4a | 438190-29-5 | Z)-SMI-4a (the Z-enantiomer of SMI-4a), a novel benzylidene-thiazolidine-2, 4-dione small molecule, is a potent and selectivePim1inhibitorwith potential antineoplastic activity. |
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V0442 | AZD1208 | 1204144-28-4 | AZD1208 is a novel, highly selective,ATP-competitiveand orally bioavailable small molecule pan-inhibitor of Pim kinase with potential antitumor activity. |
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V4239 | AZD1208 hydrochloride | 1621866-96-3 | AZD1208 hydrochloride is a novel, potent, highly selective and orally bioavailable small molecule pan-inhibitor of Pim kinase with IC50 of 0.4 nM, 5 nM, and 1.9 nM for Pim1, Pim2, and Pim3 in cell-free assays, respectively. |
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V130722 | BTK-IN-48 | 3114078-55-3 | BTK-IN-48 is a BTK inhibitor with an IC50 value of 1.14 μM. |
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V131267 | CDK2/PIM1-IN-1 | CDK2/PIM1-IN-1 is an inhibitor of CDK2 (IC50: 0.27 μM) and PIM1 (IC50: 0.67 μM) kinases. | |
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V131289 | CDK6/PIM1-IN-1 hydrochloride | 2677026-15-0 | CDK6/PIM1-IN-1 hydrochloride is an orally effective and potent dual CDK6/PIM1 inhibitor with IC50 values of 39 nM and 88 nM, respectively. |
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V112337 | CSH-4044 | CSH-4044 can be isolated from fermented wheat germ extract. | |
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V2552 | CX-6258 | 1202916-90-2 | CX-6258 is a novel, potent, selective and orally bioactive pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively. |
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V33131 | CX-6258 hydrochloride hydrate | 1353858-99-7 | CX-6258 HCl hydrate is a novel, potent, selective and orally bioactive pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively. |
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V0443 | CX-6258 HCl | 1353859-00-3 | CX-6258 HCl(known also as CX-6258 hydrochloride) is a novel, highly potent and orally bioactive pan-Pim kinase inhibitor with potential anticancer activity. |
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V74379 | FD1024 | 1422456-47-0 | FD1024 is a PIM inhibitor (IC50s for PIM1, 2, and 3 are 1.96, 38.9, and 4.17 nM). |
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V114915 | GDC-0570 | 1586041-58-8 | GDC-0570 is a novel, highly effective, selective, and orally available pan-PIM inhibitor. |
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V67542 | GSK-3β inhibitor 13 | 2227316-74-5 | GSK-3β inhibitor 13 (compound 47) is an orally bioactive and potent GSK-3β inhibitor (antagonist) with blood-brain permeability. |
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V69221 | IBL-302 (AMU302) | 1414455-21-2 | IBL-302 (AMU302) is an orally bioavailable dual-signal inhibitor of PIM and PI3K/AKT/mTOR with activity against breast cancer and neuroblastoma. |
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V4089 | INCB053914 | 1620012-39-6 | INCB053914 is a novel, potent, selective, and ATP-competitive small molecule pan-inhibitor ofPIM (Proviral Integration site of Moloney murine leukemia virus) kinaseswith IC50 values of 0.24 nM, 30 nM and 0.12 nM for PIM1, PIM2 and PIM3 respectively in biochemical assays. |
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V4088 | INCB053914 phosphate | 2088852-47-3 | INCB053914 is a novel, potent, selective, and ATP-competitive small molecule pan-inhibitor ofPIM (Proviral Integration site of Moloney murine leukemia virus) kinaseswith IC50 values of 0.24 nM, 30 nM and 0.12 nM for PIM1, PIM2 and PIM3 respectively in biochemical assays. |
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V114340 | JP-11646 | 1902983-63-4 | JP-11646 is a pan-PIM inhibitor with significantly enhanced inhibitory efficacy against PIM2 (IC50 = 0.5 nM). |
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V74391 | MNK/PIM-IN-1 | 2430792-91-7 | MNK/PIM-IN-1 is a novel MNK/PIM dual (bifunctional) inhibitor (antagonist) with good pharmacokinetic characteristics. |
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V116237 | NMS-P645 | 1482518-95-5 | NMS-P645 is a PIM1 inhibitor. |
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