The PIM kinase, also known as serine/threonine kinase, is present in three distinct isoforms, namely PIM-1, PIM-2, and PIM-3. It is a key player in the biology of cancer. Pim kinases are primarily in charge of controlling the cell cycle, antiapoptotic activity, and receptor tyrosine kinase homing and migration via the JAK/STAT pathway.
Pim kinases control the activation of signaling pathways that are crucial for tumor cell proliferation, survival, and expression of drug efflux proteins. They are overexpressed in a variety of tumor types. Pim kinases are therefore desirable targets for the creation of anti-cancer chemotherapeutic drugs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V74389 | PIM1-IN-3 | 2762767-56-4 | PIM1-IN-3 (Compound HL8) is a potent PIM1 inhibitor. |
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V74382 | PIM1-IN-4 | 2762767-48-4 | PIM1-IN-4 (Compound 8) is a potent PIM1 inhibitor. |
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V25157 | Pim1/AKK1-IN-1 | 1093222-27-5 | Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor, targeting Pim1, AKK1, MST2, LKB1, MPSK1, and TNIK. |
|
V2737 | PIM447 dihydrochloride | 1820565-69-2 | PIM447 2HCl (also known as LGH447 dihydrochloride), thedihydrochloride salt of PIM447, is a novel and potent pan-PIM (proviral insertion site of Moloney murine leukemia)kinase inhibitor with Ki values of 6 pM, 18 pM, 9 pM for PIM1, PIM2, PIM3 respectively. |
|
V28848 | Quercetagetin | 90-18-6 | Quercetagetin (6-Hydroxyquercetin) is a naturally occurring flavonoid and the major component isolated from Citrus unshiu (C. |
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V74387 | R8-T198wt | 2305815-72-7 | R8-T198wt is a cell-penetrating/penetrable, carboxy-terminal p27Kip1 peptide that displays anti-tumor effects by inhibiting Pim-1 kinase. |
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V4044 | SMI-16a | 587852-28-6 | SMI-16a (Pim1/2 Inhibitor IV) is a novel, potent, selective, cell-permeable, ATP-competitivePimkinase inhibitor withIC50values of 0.15, 0.02 and 48 μM for Pim1, Pim2 and PC3 cells, respectively. |
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V2979 | TCS PIM-1 1 | 491871-58-0 | TCS PIM-1 1, also known as sc-204330, is a highly potent substituted pyridone and selective ATP-competitive inhibitor of Pim-1 kinase with IC50 of 50 nM, it displays good selectivity over Pim-2 and MEK1/MEK2(IC50s >20,000 nM). |
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V3233 | TCS-PIM-1-4a (SMI-4a) | 327033-36-3 | TCS-PIM-1-4a ( (the mixture of E- and Z-enantiomers of SMI-4a) is a novel Pim inhibitor with IC50of 13 nM for Pim-1 and 2.3 μM for Pim-2. |
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V3019 | TP-3654 | 1361951-15-6 | TP-3654 is a novel and potent inhibitor of Pim-1 and Pim-3 (proviral integration site for moloney murine leukemia virus) kinase that is potentially useful for the treatment of various cancers such as prostate cancer, acute myeloid leukemia, multiple sclerosis and psoriasis. |
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