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| 5mg |
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| Targets |
Multiple potential targets including inflammatory mediators and signaling pathways. As a chalcone flavonoid, 4-Methoxylonchocarpin may interact with various cellular targets involved in inflammation, oxidative stress, and cell signaling. Chalcones are known to modulate multiple pathways including NF-κB, MAPK, and PI3K/Akt signaling, and to interact with enzymes such as cyclooxygenases and lipoxygenases.
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| ln Vitro |
As a chalcone flavonoid, 4-Methoxylonchocarpin may exhibit various biological activities including anti-inflammatory, antioxidant, and anticancer properties. Chalcones are known to inhibit pro-inflammatory mediators, scavenge free radicals, and modulate cell proliferation and apoptosis pathways. Specific in vitro activity data for 4-Methoxylonchocarpin is limited in the available literature.
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| ln Vivo |
In vivo, 4-Methoxylonchocarpin, as a chalcone flavonoid, may exert anti-inflammatory, antioxidant, and other pharmacological effects. Chalcones have been studied in various animal models of inflammation, cancer, and metabolic diseases. Specific in vivo data for 4-Methoxylonchocarpin is limited in the available literature.
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| Enzyme Assay |
In vitro enzyme inhibition or receptor binding assays can be performed to characterize the interaction of 4-Methoxylonchocarpin with potential molecular targets. These assays may include testing against inflammatory enzymes (COX, LOX), kinases, or receptors involved in disease pathways. The compound's ability to inhibit specific targets would be determined using purified enzymes or receptor-binding assays.
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| Cell Assay |
Cellular assays for 4-Methoxylonchocarpin would involve treating relevant cell lines with the compound and measuring effects on cell viability, inflammation, oxidative stress, and signaling pathways. Readouts may include inhibition of pro-inflammatory cytokine production, reduction of reactive oxygen species, and modulation of cell proliferation and apoptosis. These assays would confirm the compound's biological activity in a cellular context.
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| Animal Protocol |
In vivo efficacy of 4-Methoxylonchocarpin would be evaluated in animal models of inflammation, cancer, or other diseases. The compound could be administered orally or via injection, and its effects on disease progression, inflammatory markers, and other relevant endpoints would be assessed. Specific in vivo data for 4-Methoxylonchocarpin is limited in the available literature.
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| ADME/Pharmacokinetics |
4-Methoxylonchocarpin is a natural chalcone compound with a molecular formula of C21H22O4 and a molecular weight of 338.40. As a flavonoid, its pharmacokinetic properties would be characteristic of this class, with potential for oral absorption and metabolism in the gut and liver. The compound is for research use only and is not intended for human therapeutic use.
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| Toxicity/Toxicokinetics |
No specific toxicity data is available for 4-Methoxylonchocarpin. As a natural flavonoid, it is generally considered to have low toxicity, though this has not been systematically evaluated. Standard safety precautions should be observed when handling this research compound.
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| References | |
| Additional Infomation |
4-Methoxylonchocarpin is a member of the chalcone family. 4-Methoxylonchocarpin has been reported in Spatholobus suberectus and Dorstenia mannii, and available data are available.
4-Methoxylonchocarpin (CAS#: 51589-67-4) is a natural chalcone compound belonging to the flavonoid family. It has a molecular formula of C21H22O4 and a molecular weight of 338.40. As a chalcone flavonoid, it may exhibit various biological activities including anti-inflammatory, antioxidant, and anticancer properties. It is a research tool and is not approved for clinical use. |
| Molecular Formula |
C21H20O4
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|---|---|
| Molecular Weight |
336.38
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| Exact Mass |
336.136
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| CAS # |
51589-67-4
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| PubChem CID |
10472189
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| Appearance |
Light yellow to yellow solid powder
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| LogP |
4.481
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
25
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| Complexity |
528
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| Defined Atom Stereocenter Count |
0
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| SMILES |
COC1=CC=C(/C=C/C(C2C=CC3OC(C=CC=3C=2O)(C)C)=O)C=C1
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| InChi Key |
XEVCTBKORYCFCZ-UXBLZVDNSA-N
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| InChi Code |
InChI=1S/C21H20O4/c1-21(2)13-12-17-19(25-21)11-9-16(20(17)23)18(22)10-6-14-4-7-15(24-3)8-5-14/h4-13,23H,1-3H3/b10-6+
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| Chemical Name |
(E)-1-(5-hydroxy-2,2-dimethylchromen-6-yl)-3-(4-methoxyphenyl)prop-2-en-1-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
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| Solubility (In Vivo) |
Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.
Injection Formulations
Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)(e.g. IP/IV/IM/SC) *Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More
Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Oral Formulations
Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More
Oral Formulation 3: Dissolved in PEG400 (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9728 mL | 14.8641 mL | 29.7283 mL | |
| 5 mM | 0.5946 mL | 2.9728 mL | 5.9457 mL | |
| 10 mM | 0.2973 mL | 1.4864 mL | 2.9728 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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