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Structure Cat No. Product Name CAS No. Product Description
(4E)-SUN9221 V4573 (4E)-SUN9221 222318-55-0 (4E)-SUN9221 is a potent α1-adrenergic receptor and 5-HT2 receptor blocker (antagonist) with anti-hypertensive (blood pressure lowering) and antiplatelet aggregation effects.
(±)-BI-D V4720 (±)-BI-D 1416258-16-6 (±)-BI-D is a novel and potent allosteric/noncatalytic site integrase inhibitor that binds integrase at the LEDGF/p75 binding site.
5-胆烯酸-3beta-醇甲酯,3-甲酯 V5159 L 601920-0 (Methyl-3β-hydroxycholenate) 20231-57-6 Methyl-3β-hydroxycholenate is a ROR gamma modulator.
5Z-7-Oxozeaenol V4605 5Z-7-Oxozeaenol 253863-19-3 5Z-7-Oxozeaenol, a natural anti-protozoan compound isolated from fungae, is a novel, potent irreversible / covalent and selective inhibitor ofTAK1andVEGF-R2withIC50s of 8 nM and 52 nM, respectively.
A-437203 V4657 A-437203 220519-06-2 A-437203 is a novel, potent and selectiveD3receptor antagonist withKiof 71, 1.6, and 6220 nM for D2, D3, and D4receptors, respectively.
ABBV-4083 V4566 ABBV-4083 1809266-03-2 ABBV-4083, a Tylosin A analog withimprovements in anti-Wolbachiaand anti-filarial activity and oral pharmacokinetic properties, is a novel macrofilaricidal agent which acts by targeting the worm-symbiont Wolbachia bacterium.
ACY-1083 V4690 ACY-1083 1708113-43-2 ACY-1083 is a novel, potent, selective and brain-penetrant HDAC6 inhibitor with an IC50 of 3 nM.
ACY-957 V4689 ACY-957 1609389-52-7 ACY-957 is a novel, potent and selective inhibitor ofHDAC1andHDAC2isoforms withIC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively.
Ajulemic acid V4985 Ajulemic acid 137945-48-3 Ajulemic acid (also known as lenabasum) is a cannabinoid CB2 receptor agonist with the potential for treatment of skin-predominant dermatomyositis.
AMG2850 V4738 AMG2850 1470018-52-0 AMG2850 is a novel, potent, orally bioavailable and selectivesmall molecule antagonist oftransient receptor potential melastatin 8 (TRPM8).
AMY-101 V4846 AMY-101 1427001-89-5 AMY-101 (also known as Cp40) is a peptidic inhibitor of the central complement component C3.
ANT431 V5051 ANT431 1639972-90-9 ANT431 is a novel and potent inhibitor of metallo-β-lactamase with the potential for the treatment of carbapenem-resistant enterobacteriaceae infections.
ARN 077 V4565 ARN 077 1373625-34-3 ARN 077 (ARN-077) is a novel, potent and selectiveN-acylethanolamine acid amidase (NAAA)inhibitor with anIC50of 7 nM for human NAAA.
AZD3147 V4991 AZD3147 1101810-02-9 AZD3147 (AZD-3147) is an highly potent and selective dual inhibitor of mTORC1/2 with IC50 of 1.5 nM.
AZD3458 (PI3Kγ inhibitor 3) V4982 AZD3458 (PI3Kγ inhibitor 3) 2132961-46-5 AZD-3458 (PI3Kγ inhibitor 3) is a novel, potent, orally bioavailable and highly isoform selectivePI3Kγinhibitor with anticancer activity.
Bamirastine V4601 Bamirastine 215529-47-8 Bamirastine (also known as TAK-427),a new imidazopyridazine derivative, is a novelantihistamine compound withantiallergic effects.
BEBT-908 V4993 BEBT-908 1235449-52-1 BEBT-908,extracted from patent US/20120088764A1, Compound example 243, is a novel, potent and selectivePI3Kαinhibitor with anIC50<0.1 μM, it also inhibits HDAC with 0.1 μM≤IC50≤1 μM.
BGB-102 V4519 BGB-102 807640-87-5 JNJ-26483327 (also known as BGB102; JNJ26483327; BGB-102) is a novel, potent, reversible and orally bioavailable small-molecule multitargeted tyrosine kinase inhibitor againstEGFR,HER2, andHER4withIC50s of 9.6 nM, 18 nM and 40.3 nM, respectively.
BI-0252 V4702 BI-0252 1818291-27-8 BI-0252 is a novel, potent, highly selective, orally bioactiveMDM2-p53interaction inhibitor with anIC50of 4 nM.
BI-1408 V4714 BI-1408 2231075-94-6 BI-1408, atetrahydroindazole derivative, is a novel,centrally efficacious and potentγ secretasemodulator with anIC50of 0.04 μM forAβ42.
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