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    ABBV-4083
    ABBV-4083

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4566
    CAS #: 1809266-03-2Purity ≥98%

    Description: ABBV-4083, a Tylosin A analog with improvements in anti-Wolbachia and anti-filarial activity and oral pharmacokinetic properties, is a novel macrofilaricidal agent which acts by targeting the worm-symbiont Wolbachia bacterium. Chemical modification of TylA leads tos; ABBV-4083 has been selected for clinical evaluation.There is a significant need for improved treatments for onchocerciasis and lymphatic filariasis, diseases caused by filarial worm infection. In particular, an agent able to selectively kill adult worms (macrofilaricide) would be expected to substantially augment the benefits of mass drug administration (MDA) with current microfilaricides, and to provide a solution to treatment of onchocerciasis / loiasis co-infection, where MDA is restricted.  

    References:  2019 Feb 28;13(2):e0007159. 

    Related CAS : 1809266-03-2; 1401-69-0 (Tylosin A)

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    ABBV-4083

    Molecular Weight: 1024.21
    Formula: C₅₃H₈₂FNO₁₇
    CAS No.: 1809266-03-2
    SMILES: O[[email protected]@H]1[[email protected]@H](C)O[[email protected]](OC[[email protected]]([[email protected]@H](CC)OC(C[[email protected]]([[email protected]@H]([[email protected]]([[email protected]@H](CC=O)C[[email protected]]2C)O[[email protected]]3([H])O[[email protected]](C)[[email protected]@H](O[[email protected]]4([H])O[[email protected]@H](C)[[email protected]](OCC5=CC=C(F)C=C5)[[email protected]@](O)(C)C4)[[email protected]](N(C)C)[[email protected]]3O)C)O)=O)/C=C(C)/C=C/C2=O)([H])[[email protected]](OC)[[email protected]@H]1OC
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationABBV-4083; ABBV 4083; ABBV4083


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