| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
|
| Targets |
Akt1 (EC50 = 33.3 μM)
24-Methylene cycloartanyl ferulate targets multiple pathways. It is a potential ATP-competitive Akt1 inhibitor with an EC50 of 33.3 μM. It also promotes parvin-beta expression in human breast cancer cells, suggesting a role in cell adhesion and signaling. Its antioxidant and anti-inflammatory properties are attributed to the ferulic acid moiety. |
|---|---|
| ln Vitro |
In vitro, 24-MCAF promotes parvin-beta expression in human breast cancer cells and acts as an Akt1 inhibitor (EC50 = 33.3 μM). These activities make it a useful tool for studying cancer cell biology.
|
| ln Vivo |
In vivo data for 24-MCAF is not provided in the available literature.
|
| Enzyme Assay |
The Akt1 inhibitory activity of 24-MCAF is assessed using kinase assays. Its effect on parvin-beta expression is measured by Western blot or qRT-PCR in cell lines.
|
| Cell Assay |
The cellular activity of 24-MCAF is evaluated in cancer cell lines. Its effect on cell signaling and viability is assessed.
|
| ADME/Pharmacokinetics |
Pharmacokinetic properties of 24-MCAF are not detailed.
|
| Toxicity/Toxicokinetics |
No toxicology data is provided.
|
| References | |
| Additional Infomation |
Oryzanol C is a triterpenoid compound.
24-Methylene cycloartanyl ferulate (CAS: 469-36-3) is a bioactive compound from rice bran oil with antioxidant, anti-inflammatory, and potential anticancer properties. |
| Molecular Formula |
C41H60O4
|
|---|---|
| Molecular Weight |
616.913
|
| Exact Mass |
616.449
|
| CAS # |
469-36-3
|
| Related CAS # |
469-36-3
|
| PubChem CID |
9920169
|
| Appearance |
White to off-white solid powder
|
| Density |
1.1±0.1 g/cm3
|
| Boiling Point |
668.4±40.0 °C at 760 mmHg
|
| Flash Point |
193.5±20.8 °C
|
| Vapour Pressure |
0.0±2.1 mmHg at 25°C
|
| Index of Refraction |
1.564
|
| LogP |
13.2
|
| Hydrogen Bond Donor Count |
1
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
10
|
| Heavy Atom Count |
45
|
| Complexity |
1170
|
| Defined Atom Stereocenter Count |
9
|
| SMILES |
C[C@H](CCC(=C)C(C)C)[C@H]1CC[C@@]2([C@@]1(CC[C@]34[C@H]2CC[C@@H]5[C@]3(C4)CC[C@@H](C5(C)C)OC(=O)/C=C/C6=CC(=C(C=C6)O)OC)C)C
|
| InChi Key |
JBSUVXVGZSMGDJ-YVMHCORFSA-N
|
| InChi Code |
InChI=1S/C41H60O4/c1-26(2)27(3)10-11-28(4)30-18-20-39(8)34-16-15-33-37(5,6)35(19-21-40(33)25-41(34,40)23-22-38(30,39)7)45-36(43)17-13-29-12-14-31(42)32(24-29)44-9/h12-14,17,24,26,28,30,33-35,42H,3,10-11,15-16,18-23,25H2,1-2,4-9H3/b17-13+/t28-,30-,33+,34+,35+,38-,39+,40-,41+/m1/s1
|
| Chemical Name |
[(1S,3R,6S,8R,11S,12S,15R,16R)-7,7,12,16-tetramethyl-15-[(2R)-6-methyl-5-methylideneheptan-2-yl]-6-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl] (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate
|
| Synonyms |
24-Methylene cycloartanyl ferulate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: ≥12.5 mg/mL (~20.3 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.25 mg/mL (2.03 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 12.5 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6210 mL | 8.1049 mL | 16.2098 mL | |
| 5 mM | 0.3242 mL | 1.6210 mL | 3.2420 mL | |
| 10 mM | 0.1621 mL | 0.8105 mL | 1.6210 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
