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MAP4K

MAP4K

MAP kinase kinase kinase kinases (MAP4Ks) belong to the mammalian Ste20-like family of serine/threonine kinases.According to studies, MAP4Ks such as MAP4K1/HPK1, MAP4K2/GCK, MAP4K3/GLK, MAP4K4/HGK, MAP4K5/KHS, and MAP4K6/MINK cause JNK activation by triggering the MAP3K-MAP2K cascade. The regulation of cell migration, autophagy, apoptosis, and survival is greatly influenced by MAP4Ks. According to a number of studies, MAP4Ks control immune-cell responses through JNK-independent pathways.

When T-cells are activated and inflammatory responses are triggered, MAP4K1/HPK1 and MAP4K4/HGK play harmful roles. In contrast, MAP4K3/GLK contributes to the activation of T cells and autoimmune responses. Additionally, human autoimmune diseases like psoriatic arthritis, rheumatoid arthritis (RA), adult-onset Still's disease, and SLE involve MAP4K1 downregulation and MAP4K3 overexpression in T cells.

MAP4K related products

Structure Cat No. Product Name CAS No. Product Description
(3S,4R)-GNE-6893 V87077 (3S,4R)-GNE-6893 2415374-97-7 (3S,4R)-GNE-6893 is an orally available HPK1 inhibitor.
6-Bromo-3-fluoropyridine-2-carbaldehyde V127361 6-Bromo-3-fluoropyridine-2-carbaldehyde 885267-36-7 6-Bromo-3-fluoropyridine-2-carbaldehyde is a synthetic intermediate.
AT-051/43421517 V129566 AT-051/43421517 1241957-37-8 AT-051/43421517 is a cell protectant and apoptosis inhibitor that binds to human phosphoglycerate kinase 1 (hPgk1).
BAY-405 V94597 BAY-405 2442532-66-1 BAY-405 (compound 38) is a MAP4K1 inhibitor that exhibits nanomolar potency in biochemical and cellular assays and achieves in vivo exposure after oral administration.
DMX-5804 V4271 DMX-5804 2306178-56-1 DMX-5804 is a novel, potent, orally bioactive and selectiveMAP4K4(Mitogen-activated protein kinase kinase kinase kinase-4) inhibitor with anIC50of 3 nM, apIC50of 8.55 for human MAP4K4, less potent on MINK1/MAP4K6 (pIC50, 8.18), and TNIK/MAP4K7 (pIC50, 7.96).
DS21150768 V77906 DS21150768 DS21150768 is a potent orally bioactive HPK1 inhibitor.
GNE-1858 V74401 GNE-1858 2680616-96-8 GNE-1858 is a potent ATP-competitive hematopoietic progenitor cell kinase-1 (HPK1) inhibitor, with IC50s of 1.9 nM, 1.9 nM, and 4.5 against wild-type and active mimic mutant strains HPK1-TSEE and HPK1-SA, respectively.
GNE-495 V4550 GNE-495 1449277-10-4 GNE-495 is a novel, potent and selectiveMAP4K4(mitogen-activated protein kinase kinase kinase kinase 4) inhibitor with anIC50of 3.7 nM.Diverse biological roles for mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) have necessitated the identification of potent inhibitors in order to study its function in various disease contexts.
GNE-6893 V74424 GNE-6893 2415374-98-8 GNE-6893 is an orally bioavailable HPK1 inhibitor.
HDM2004 V137236 HDM2004 2953016-30-1 HDM2004 is a highly selective, orally effective, blood-brain barrier-crossing HPK1 inhibitor with an IC50 value of 1.89 nM.
HMC-B17 V87083 HMC-B17 2935913-83-8 HMC-B17 is a selective, orally bioavailable HPK1 inhibitor (IC50 = 1.39 nM) that enhances anti-PD-L1 efficacy.
HPK1 antagonist-1 V74416 HPK1 antagonist-1 2628489-56-3 HPK1 antagonist-1 (I-792) is an Hpk1 antagonist that may be utilized in cancer and immune disease study.
HPK1 ligand 3 V137509 HPK1 ligand 3 HPK1 ligand 3 is a ligand for the target protein of PROTAC and can be used to synthesize PROTAC HPK1 degrader-4.
HPK1 ligand 4 V119094 HPK1 ligand 4 HPK1 ligand 4 is a PROTAC target protein ligand that can be used to synthesize PROTACs, such as PROTAC HPK1 degrader-5.
HPK1 ligand 6 V116635 HPK1 ligand 6 3056139-31-9 HPK1 ligand 6 is an HPK1 ligand.
HPK1 ligand-Linker Conjugate 1 V119247 HPK1 ligand-Linker Conjugate 1 3061690-80-7 HPK1 ligand-linker conjugate 1 is a synthetic target protein ligand-linker complex that can be used to synthesize PROTACs, such as PROTAC HPK1 degrader-5.
HPK1-IN-10 V74410 HPK1-IN-10 2734168-69-3 HPK1-IN-10 is an effective HPK1 inhibitor.
HPK1-IN-11 V74403 HPK1-IN-11 2734167-68-9 HPK1-IN-11 is an effective HPK1 inhibitor.
HPK1-IN-12 V74412 HPK1-IN-12 2734168-51-3 HPK1-IN-12 is an effective HPK1 inhibitor.
HPK1-IN-13 V74407 HPK1-IN-13 2734168-30-8 HPK1-IN-13 is an effective HPK1 inhibitor.
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