JNK

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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JNK

JNK (c-Jun N-terminal kinase), a kinase subfamily belonging to the MAPK, is activated in response to various stress stimuli and possesses a wide variety of regulatory functions.Three isoforms of the serine/threonine protein kinase JNK family (JNK1, JNK2, and JNK3) exist. JNKs play a role in the development and progression of many pathologies, including cancer, inflammatory diseases, cardiovascular and metabolic disorders, and neurodegenerative diseases.

JNKs are triggered by a phosphorylation cascade that typically involves two different upstream kinases, the so-called MAP kinase kinase kinases (MAP3K, MKKK) and the MAP kinase kinases (MAP2K; MKK). This process is similar to that used to activate the other MAP kinases. JNKs are triggered by MKK4 and MKK7 at the MAP2K level; the former is a shared activator of the JNK and p38 MAP kinase signaling pathways. The JNK cascade is a component of a complicated signaling network since it crosses numerous other routes at different places.

JNK related products

Cat No.	Product Name	CAS No.	Product Description
V116590	JNK2 Recombinant Human Active Protein Kinase		JNK2 is a neuron-specific subtype of JNK.
V116625	JNK3 Recombinant Human Active Protein Kinase		JNK3 is a neuron-specific subtype of JNK.
V114179	GSTP1/M2-IN-1		GSTP1/M2-IN-1 is a dual inhibitor of GSTP1/GSTM2 (IC50 = 1.56 μM/0.09 μM).
V114252	JNK-IN-25	1644498-54-3	JNK-IN-25 is a highly potent and selective JNK1/2/3 inhibitor with IC50 values of 1.54 nM (JNK1), 1.99 nM (JNK2), and 0.75 nM (JNK3), respectively.
V117703	JNK-9L	1128096-64-9	JNK-9L (compound 9L) is a JNK inhibitor that can cross the blood-brain barrier and competitively bind to ATP, with IC50 values of 0.099 μM and 0.148 μM for JNK1 and JNK3, respectively.
V10399	AEG-3482	63735-71-7	AEG-3482 is a novel and potent antiapoptotic compound.
V51559	8-Hydroxy-efavirenz	205754-33-2	major metabolite of Efavirenz
V3735	AS601245	345987-15-7	AS601245 is an inhibitor of the JNK signaling pathway, it showed high JNK1/2/3 inhibition with IC50 of 150, 220, and 70 nM respectively.
V94568	AS601245 TFA	345987-16-8	AS601245 TFA is an orally active, selective, ATP-competitive JNK inhibitor with IC50 of 150, 220, and 70 nM for three human JNK isoforms (hJNK1, hJNK2, and hJNK3), respectively.
V98216	Autophagy inducer 5		Autophagy inducer 5 (compound 21o) is a potent MCF-7 inhibitor (IC50: 2 μM) and a potential breast cancer inhibitor.
V2665	BI-78D3	883065-90-5	BI-78D3 (also known as JNK Inhibitor X) is a novel, potent and competitive JNK inhibitor with IC50 of 280nM.
V96909	BSO-07		BSO-07 is a ROS/JNK activator with significant anticancer effects, with an IC50 of 24.81 μM against human breast cancer (BC) cells.
V2078	CC-401	395104-30-0	CC-401 (CC401) is a potent, specific, 2nd generation and ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity.
V2978	CC-401 HCl	1438391-30-0	CC-401 HCl (CC401 hydrochloride) is an anthrapyrazolone-based inhibitor of c-Jun N terminal kinase (JNK) with potential anticancer activity.
V2263	CC-90001	1403859-14-2	CC-90001 (CC90001; CC 90001) is a novel, potent and selective inhibitor of c-Jun N-terminal kinase (JNK) with potential anti-fibrotic activity.
V87071	CMX-8933	146877-90-9	CMX-8933 is an octapeptide fragment of the goldfish brain neurotrophic factor ependymin.
V19209	DB07268	929007-72-7	DB07268 is a potent and specific JNK1 inhibitor (antagonist) with IC50 of 9 nM.
V80005	DN-1289	3026597-15-6	DN-1289 is an orally bioactive, selective inhibitor targeting dileucine zipper kinase (DLK; IC50=17 nM) and leucine zipper-bearing kinase (LZK; IC50=40 nM).
V0474	DTP3	1809784-29-9	DTP3 (DTP-3) is a novel, potent and selective inhibitor of GADD45β/MKK7 ((growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) with potential anticancer activity.
V22646	IQ-1S	23146-22-7	IQ-1S is a potent and selective c-Jun N-Terminal Kinase Inhibitor.