ERKs (Extracellular-signal-regulated kinases) are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells.The ERK pathway is activated by a wide range of stimuli, including as growth factors, cytokines, viral infection, ligands for heterotrimeric G protein-coupled receptors, transforming agents, and carcinogens. Ras stimulates c-Raf in the MAPK/ERK pathway, which is subsequently joined by mitogen-activated protein kinase kinase (also known as MKK, MEK, or MAP2K), followed by MAPK1/2 (see below).
Ras can be triggered by additional cues in addition to growth hormones through GRB2/SOS and receptor tyrosine kinases. Many transcription factors, including ELK1, and some downstream protein kinases are known to be activated by ERKs. Ras, c-Raf, and receptors like HER2 are known to cause disruption of the ERK pathway, which is frequently seen in malignancies.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V69775 | Larixol ((+)-Larixol) | 1438-66-0 | Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. |
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V69808 | Laxiflorin B | 165337-71-3 | Laxiflorin B is a Chinese herbal compound that can selectively inhibit ERK1/2 and has anti-tumor activity. |
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V80541 | Laxiflorin B-4 | Laxiflorin B-4 is a modified compound of Laxiflorin B with higher affinity for ERK1/2 and stronger tumor inhibitory activity. | |
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V69813 | MEK1 Derived Peptide Inhibitor 1 | 355367-87-2 | MEK1 Derived Peptide Inhibitor 1 is a bioactive peptide inhibitor. |
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V80769 | MHJ-627 | MHJ-627 is a potent ERK5 (MAPK7) inhibitor (IC50= 0.91 μM). | |
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V4122 | MK-8353 | 1184173-73-6 | MK-8353 (also known as SCH900353; SCH-900353) is a novel, potent, selective and orally bioavailable ERK inhibitor with anticancer activity. |
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V80864 | Myristoyl-MEK1 Derived Peptide Inhibitor 1 | Myristoyl-MEK1 Derived Peptide Inhibitor 1 is the myristoylated form of MEK1 Derived Peptide Inhibitor 1. | |
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V69800 | Pamoic acid disodium (disodium pamoate; disodium acetylate; disodium pamoic acid salt) | 6640-22-8 | Pamoic acid disodium is a potent GPR35 agonist/activator with EC50 of 79 nM. |
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V5279 | Piperlongumine (Piplartine) | 20069-09-4 | Piperlongumine (Piplartine) is a naturally occuring and biologically active alkaloid isolated from peppers especcially long peppers such as Piper longum Linn, which possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities. |
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V69822 | POP-3MB | 1144114-27-1 | POP-3MB (compound 1b) is an isoprenylcysteine carboxyl methyltransferase (ICMT) inhibitor (IC50= 2.5 μM). |
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V69811 | Prolylserine | 71835-80-8 | Prolylserine is a dipeptide that is an inhibitor (blocker/antagonist) of melanin production in Mel-Ab cells. |
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V0466 | Ravoxertinib (GDC-0994; RG-7842) | 1453848-26-4 | Ravoxertinib (formerly known as GDC0994; RG7842) is a novel, potent, orally bioavailable inhibitor of extracellular signal-regulated kinase (ERK1/2) with potential antineoplastic activity. |
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V4529 | Ravoxertinib hydrochloride (GDC-0994; RG7842) | 2070009-58-2 | Ravoxertinib hydrochloride (GDC-0994; RG-7842), the hydrochloride salt of Ravoxertinib, is an orally bioavailable inhibitor of extracellular signal-regulated kinase (ERK1/2) being developed as an anticancer drug. |
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V4794 | Rineterkib (LTT-462; ERK-IN-1) | 1715025-32-3 | Rineterkib (LTT-462; ERK-IN-1; ERK-IN1), the compound B extracted from WO2018051306A1, is a novel and potent RAF and ERK1/2 inhibitor with anticancer activity. |
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V51449 | Rineterkib hydrochloride | 1715025-34-5 | ERK1/2 inhibitor |
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V0463 | SCH772984 | 942183-80-4 | SCH772984 (SCH-772984) is a novel, potent and ATP-competitive inhibitor of ERK1/2 with potential antitumor activity. |
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V69743 | SHP2-IN-23 | 2415989-91-0 | SHP2-IN-23 (compound 30) is an orally bioactive SHP2 inhibitor (IC50=38 nM) with excellent in vivo activity and pharmacokinetic characteristics. |
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V69831 | SHR2415 | 2494010-42-1 | SHR2415 is a potent and specific ERK1/2 inhibitor (antagonist) with oral activity. |
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V1890 | Sodium Tauroursodeoxycholate (TUDC) | 35807-85-3 | Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, which is used for the treatment of gallstones and liver cirrhosis. |
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V69824 | STE-MEK1(13) (Ste-MPKKKPTPIQLNP-NH₂; ERK Activation Inhibitor Peptide) | 566872-15-9 | STE-MEK1(13) (Ste-MPKKKPTPIQLNP-NH2) is a cell-penetrating/penetrable ERK1/2 inhibitor (IC50= 13-30μM). |
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