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    Sodium Tauroursodeoxycholate (TUDC)
    Sodium Tauroursodeoxycholate (TUDC)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1890
    CAS #: 35807-85-3 Purity ≥98%

    Description: Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, which is used for the treatment of gallstones and liver cirrhosis. In vitro, Tauroursodeoxycholate shows protective and reversing effects on 17βEG-induced impairment of the cVA-of-CLF. In Mz-ChA-1 cholangiocarcinoma cells, Tauroursodeoxycholate inhibits cell growth via Ca2+-, PKC-, and MAPK-dependent pathways. In isolated rat hepatocytes, Tauroursodeoxycholate inhibits bile acid-Induced Apoptosis via a β1-integrin-mediated formation of cAMP.

    References: J Hepatol. 2001 Feb;34(2):184-91; Eur J Pharmacol. 2001 Jun 1;421(1):55-60; Am J Physiol Gastrointest Liver Physiol. 2004 Jun;286(6):G973-82.

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    Molecular Weight (MW)521.69 
    FormulaC26H44NNaO6S 
    CAS No.35807-85-3 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (191.7 mM) 
    Water: 100 mg/mL (191.7 mM) 
    Ethanol: 71 mg/mL (136.1 mM) 
    SMILESC[[email protected]](CCC(NCCS(=O)([O-])=O)=O)[[email protected]]1CC[[email protected]@]2([H])[[email protected]]3([H])[[email protected]@H](O)C[[email protected]]4([H])C[[email protected]](O)CC[[email protected]]4(C)[[email protected]@]3([H])CC[[email protected]]12C.[Na+]
    SynonymsTUDC; Sodium tauroursodeoxycholate; Tauroursodeoxycholic acid sodium salt


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    In Vitro

    In vitro activity: In vitro, Tauroursodeoxycholate shows protective and reversing effects on 17βEG-induced impairment of the cVA-of-CLF. In Mz-ChA-1 cholangiocarcinoma cells, Tauroursodeoxycholate inhibits cell growth via Ca2+-, PKC-, and MAPK-dependent pathways. In isolated rat hepatocytes, Tauroursodeoxycholate inhibits bile acid-Induced Apoptosis via a β1-integrin-mediated formation of cAMP.


    Cell Assay: After trypsinization, Mz-ChA-1 cells are suspended in CCM at 5 × 104 cells/mL, and 200 μL of the cell suspension are seeded into flat-bottomed 96-well plates. After an initial incubation step of 4 h at 37°C in a 5% CO2 incubator, the cells are incubated at 37°C with TUDCA (0.2–200 μM). After incubation for 24–96 h, [3H]thymidine is put into each well at 5.0 μCi/mL and incubated for additional 4 h. [3H]thymidine incorporation is measured by a scintillation counter. At the end of each incubation period, cell viability is evaluated by trypan blue exclusion.

    In VivoIn phalloidin-induced cholestasis rats, Tauroursodeoxycholate (360 μmol/kg, i.v.) significantly suppresses the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations. 
    Animal modelPhalloidin-induced cholestasis rats 
    Formulation & DosageDissolved in saline; 360 μmol/kg; i.v. injection
    References

    J Hepatol. 2001 Feb;34(2):184-91; Eur J Pharmacol. 2001 Jun 1;421(1):55-60; Am J Physiol Gastrointest Liver Physiol. 2004 Jun;286(6):G973-82. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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