The components of drug-linker conjugates for antibody drug conjugates (ADCs) are a cytotoxic drug that is active and a suitable linker. These conjugates can be used to create ADCs, which are highly selective and cytotoxic agents that are targeted for cancer cells after being joined to a monoclonal antibody.
The drug units in drug-linker conjugates are tubulin inhibitors and DNA damaging agents that have antitumor activity (i.e., ADC cytotoxins or payloads). Auristatins and Maytansinoids are the most widely used tubulin inhibitors, while Duocarmycins, Pyrrolobenzodiazepines, Camptothecines, and Daunorubicins/Doxorubicines are the most frequently used DNA damaging agents in ADCs. Additionally, a variety of conventional cytotoxic agents can be used in ADCs.
Cleavable and noncleavable ADC linkers are the two categories into which the majority of those currently undergoing clinical evaluation fall. Noncleavable linkers necessitate proteolytic degradation of the antibody component of the ADC in order to release the cytotoxic molecule, whereas cleavable linkers depend on cellular processes to release the toxin.
Structure | Cat No. | Product Name | CAS No. | Product Description |
---|---|---|---|---|
V54768 | MC-DOXHZN ((E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone) | 151038-96-9 | MC-DOXHZN ((E/Z)-Aldoxorubicin) is the albumin-bound precursor of Doxorubicin, a DNA topoisomerase II inhibitor, and is acid-sensitive. | |
V54798 | MC-EVCit-PAB-MMAE | 2873452-49-2 | MC-EVCit-PAB-MMAE (Linker-Payload 11) is an ADC . | |
V54799 | MC-GGFG-(7ethanol-10NH2-11F-Camptothecin) | 2873460-72-9 | MC-GGFG-(7ethanol-10NH2-11F-Camptothecin) (compound 141) is a drug-linker conjugate for ADC, which is composed of 7ethanol-10NH2-11F-Camptothecin and protease cleavable MC-GGFG. | |
V54761 | MC-GGFG-AM-(10Me-11F-Camptothecin) | 2873460-70-7 | MC-GGFG-AM-(10Me-11F-Camptothecin) is a Linker-Payload conjugate used in the synthesis/preparation of ZW251. | |
V54758 | MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan | 2414254-51-4 | MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan is part of a drug-linker conjugate for ADC, containing Exatecan . | |
V54785 | MC-Gly-Gly-Phe-Gly-(S)-Cyclopropane-Exatecan | 2414254-52-5 | MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan is a part of the antibody conjugate active molecule (drug-linker conjugate for ADC)such as Exatecan . | |
V52928 | MC-SN38 | 1473403-87-0 | MC-SN38 is an active molecular conjugate consisting of the potent microtubule-destroying agent SN38 and a non-cleavable (non-degradable) MC linker. | |
V76781 | Mc-Val-Cit-PAB-Gefitinib chloride | Mc-Val-Cit-PAB-Gefitinib chloride is an ADC drug-linker conjugate (drug-linker conjugates for ADC). | ||
V51227 | MC-Val-Cit-PAB-MMAF (Vc-MMAF) | 863971-17-9 | drug-linker conjugate | |
V54754 | MC-VC-PAB-Cyclohexanediamine-Thailanstatin A | 1609108-96-4 | MC-VC-PAB-Cyclohexanediamine-Thailanstatin A is a splicing statin analog and a drug-linker conjugate constituting ADC, consisting of ADC cytotoxic Thailanstatin A and consisting of cleaved ADC linker (MC-vc-PAB). | |
V80722 | MC-VC-PAB-MMAD | MC-VC-PAB-MMAD is part of an antibody-active molecule conjugate, which is connected by the microtubule inhibitor MMAD and the degradable ADC linker MC-VC-PAB. | ||
V52449 | Mc-VC-PAB-SN38 | 1801838-28-7 | Mc-VC-PAB-SN38 is made up of cleavable ADC (Antibody-drug conjugate) linker (Mc-VC-PAB) and SN38, a DNA topoisomerase I inhibitor. | |
V54791 | MC-VC-PAB-Tubulysin M | 1639939-56-2 | MC-vc-PAB-Tubulysin M is made up of a cleavable ADC (Antibody-drug conjugate) linker (MC-vc-PAB) and a cytotoxic molecule, the tubulin inhibitor Tubulysin M . | |
V54780 | MC-VC-PABC-C6-alpha-Amanitin | 2922514-69-8 | MC-VC-PABC-C6-alpha-Amanitin is an antibody active molecular conjugate (ADC) consisting of the anti-cancer toxin alpha-Amanitin and the monoclonal antibody (mAb) MC-VC-PABC-C6. | |
V53075 | MCC-DM1 | 1100692-14-5 | MCC-DM1 is a bioactive molecule-linker conjugate used for ADC synthesis, like used for the synthesis of Anti-CD22-MCC-DM1. | |
V51087 | Mipsagargin (G-202) | 1245732-48-2 | thapsigargin-based PDC targeting PSMA | |
V51232 | Modified MMAF-C5-COOH | 1404071-65-3 | Modified MMAF-C5-COOH is a drug-linker conjugate for ADC. | |
V54789 | mp-dLAE-PABC-MMAE | 2625616-44-4 | mp-dLAE-PABC-MMAE is part of the active molecule for antibody conjugation. | |
V54759 | MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT | 2378428-19-2 | MP-PEG4-Val-Lys-Gly-7-MAD-MDCPT, a camptothecin-linker compound, is part of the drug-linker conjugate for ADC. | |
V80833 | Mp-polymer ester | Mp-polymer ester is a non-cleavable (non-degradable) ADC linker used to synthesize Antibody-drug conjugates (ADCs). |