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Drug-Linker Conjugates for ADC

Drug-Linker Conjugates for ADC

The components of drug-linker conjugates for antibody drug conjugates (ADCs) are a cytotoxic drug that is active and a suitable linker. These conjugates can be used to create ADCs, which are highly selective and cytotoxic agents that are targeted for cancer cells after being joined to a monoclonal antibody.

The drug units in drug-linker conjugates are tubulin inhibitors and DNA damaging agents that have antitumor activity (i.e., ADC cytotoxins or payloads). Auristatins and Maytansinoids are the most widely used tubulin inhibitors, while Duocarmycins, Pyrrolobenzodiazepines, Camptothecines, and Daunorubicins/Doxorubicines are the most frequently used DNA damaging agents in ADCs. Additionally, a variety of conventional cytotoxic agents can be used in ADCs.

Cleavable and noncleavable ADC linkers are the two categories into which the majority of those currently undergoing clinical evaluation fall. Noncleavable linkers necessitate proteolytic degradation of the antibody component of the ADC in order to release the cytotoxic molecule, whereas cleavable linkers depend on cellular processes to release the toxin.

Drug-Linker Conjugates for ADC related products

Structure Cat No. Product Name CAS No. Product Description
V79577 GGGDTDTC-Mc-vc-PAB-MMAE GGGDTDTC-Mc-vc-PAB-MMAE is a drug-linker conjugate of ADC containing the tubulin inhibitor Monomethyl auristatin E (MMAE).
V53073 Glucocorticoid receptor agonist-1 Ala-Ala-Mal 2166376-51-6 Glucocorticoid receptor agonist-1 Ala-Ala-Mal (compound 88) is a glucocorticoid and a glucocorticoid receptor agonist.
V53117 Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Br 2345733-40-4 Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Br is a drug-linker conjugates for ADC and could be utilized as a reaction reagent for the synthesis of anti-CD40 antibody active molecular conjugates (ADCs).
V53387 Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal 2345732-89-8 Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Mal is a glucocorticoid receptor agonist.
V54764 Glucocorticoid receptor agonist-2 Ala-Ala-Mal 2166376-64-1 Glucocorticoid receptor agonist-2 Ala-Ala-Mal (compound 79) may be utilized to prepare anti-inflammatory ADC molecules.
V54781 Gly-Mal-Gly-Gly-Phe-Gly-amide-methylcyclopropane-Exatecan 2766786-76-7 Gly-Mal-Gly-Gly-Phe-Gly-amide-methylcyclopropane-Exatecan can be used for the synthesis of ADC.
V52440 Gly3-VC-PAB-MMAE 2684216-48-4 Gly3-VC-PAB-MMAE is made up of cleavable ADC (Antibody-drug conjugate) linker (Gly3-VC-PAB) and MMAE, which is an effective microtubule (tubulin) inhibitor.
V54770 HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM 2243689-64-5 HS-(CH2)3CO-L-Ala-D-Ala-L-Ala-NH-CH2-S-(CH2)5-CO-DM is part of the antibody coupling active molecule (drug-linker conjugate for ADC).
V76160 LP-6 1629736-79-3 LP-6 is an ADC drug-linker conjugates (Drug-Linker Conjugates for ADC) that can be used for the synthesis of ADC.
V76163 Lys-Nε-SPDB-DM4 1280215-91-9 Lys-Nε-SPDB-DM4 is a drug-linker conjugate, consisting of the potent tubulin inhibitor DM4 and the linker Lys-Nε-SPDB, used to prepare antibody active molecular conjugates (ADC).
V33339 Lys-SMCC-DM1 TFA 1281816-04-3 Lys-SMCC-DM1 is the active metabolite of T-DM1.
V81835 m-PEG-NHS ester (MW 1000) (mPEG-SC (MW 1000); mPEG-Succinimidyl ester (MW 1000)) 92451-01-9 m-PEG-NHS ester (MW 1000) may be utilized to modify active molecules and improve their antigenicity and immunogenicity to help prepare injectable preparations.
V52111 Mal-(CH2)5-Val-Cit-PAB-Eribulin 2130869-21-3 Mal-(CH2)5-Val-Cit-PAB-Eribulin is part of the antibody conjugate active molecule (drug-linker conjugate for ADC) and has anti-neoplastic activity.
V54797 Mal-amido-PEG8-Val-Ala-PAB-SG3200 2025353-40-4 Mal-amido-PEG8-Val-Ala-PAB-SG3200 is a conjugate of antibody-active molecule conjugates (information disclosed in patent WO2016166300A1).
V51217 Mal-C2-Gly3-EDA-PNU-159682 2259318-53-9 Mal-C2-Gly3-EDA-PNU-159682, a bioactive molecule-conjugate for ADC, consists of the ADC linker Mal-C2-Gly3-EDA and the potent ADC cytotoxic DMEA-PNU-159682.
V51219 Mal-C6-α-Amanitin 1578249-76-9 drug-linker conjugate for ADC
V54788 Mal-cyclohexane-Gly-Gly-Phe-Gly-Exatecan 2578019-72-2 Mal-cyclohexane-Gly-Gly-Phe-Gly-Exatecan is a coupling compound that may be utilized in the synthesis/preparation of ADC.
V52883 MAL-di-EG-Val-Cit-PAB-MMAE 2746391-62-6 MAL-di-EG-Val-Cit-PAB-MMAE is a combination of the effective microtubule inhibitor Monomethyl Auristatin E (MMAE) and the peptide linker MAL-di-EG-Val-Cit-PAB.
V76795 MAL-di-EG-Val-Cit-PAB-MMAF MAL-di-EG-Val-Cit-PAB-MMAF consists of an ADC linker (MAL-di-EG-Val-Cit-PAB) and a potent tubulin polymerization blocker (MMAF, Monomethyl auristatin F).
V52908 Mal-PEG2-Gly-Gly-Phe-Gly-Exatecan 1599439-54-9 Mal-PEG2-Gly-Gly-Phe-Gly-Exatecan is an ADC drug-linker conjugate.
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