A desirable monoclonal antibody, an effective cytotoxic drug, and a suitable linker make up antibody-drug conjugates (ADCs). A suitable linker between the antibody and the cytotoxic drug creates a clear bridge, enabling the antibody to precisely deliver the cytotoxic drug to tumor sites and deliver it only to tumor cells. In addition to conjugation, the linkers preserve the stability of ADCs during their preparation, storage, and systemic circulation phases.
The linkers found in the ADCs currently undergoing clinical evaluation are primarily divided into two groups: cleavable and noncleavable. Cleavable linkers rely on internal cellular mechanisms to release the toxin, such as cytoplasmic reduction, exposure to acidic conditions in the lysosome, or cleavage by particular cellular proteases. For the release of the cytotoxic molecule with noncleavable linkers, the antibody portion of the ADC must be broken down by proteolytic enzymes while retaining the linker and the amino acid by which it was attached to the antibody.
Based on knowledge of the internalization and breakdown of the antibody-target antigen complex and a comparison of the preclinical in vitro and in vivo activities of conjugates, the choice of linker depends on the target. Additionally, because each molecule has different chemical restrictions and frequently the drug structure lends itself to a particular linker, the choice of a linker is also influenced by the type of cytotoxin used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V76131 | SCO-PEG3-Maleimide | 2141976-35-2 | SCO-PEG3-Maleimide is a cleavable ADC (Antibody-drug conjugate) linker containing 3 PEG (polyethylene glycol) units. |
|
V76137 | SCO-PEG3-NH2 | 2141976-29-4 | SCO-PEG3-NH2 is a cleavable ADC (Antibody-drug conjugate) linker containing 3 PEG (polyethylene glycol) units. |
|
V93138 | SCO-PEG3-NH2 formate | SCO-PEG3-NH2 formate is a cleavable ADC linker containing 3 PEG units. | |
|
V76132 | SCO-PEG7-Maleimide | 2143968-81-2 | SCO-PEG7-Maleimide is a cleavable ADC (Antibody-drug conjugate) linker containing 3 PEG (polyethylene glycol) units. |
|
V96743 | SGD-9501-TFA | SGD-9501-TFA is an auristatin S-based ADC linker with an effective off-target toxicity profile for the preparation of antibody-drug conjugates (ADCs). | |
|
V11269 | SMCC crosslinker | 64987-85-5 | SMCC, formerly known as succinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate, is a heterobifunctional protein crosslinker. |
|
V111795 | SMCC-NH-CH2-triazole-PEG8-oxydiacetamide-Lys(MTT)-PAB | 2451934-98-6 | SMCC-NH-CH2-triazole-PEG8-oxodiacetamide-Lys(MTT)-PAB (page 7, compound C) is an ADC linker that can be used to synthesize antibody-coupled active molecules (ADCs). |
|
V100274 | SMP-96745 | 2760408-63-5 | SMP-96745 is a dual-drug targeting linker-drug conjugate for cancer research. |
|
V54497 | SNPB | 663598-85-4 | SNPB is a degradable linker used to prepare active antibody conjugate molecules (ADC). |
|
V54513 | SNPB-sulfo-Me | 890409-86-6 | SNPB-sulfo-Me is a degradable linker used to prepare active antibody conjugate molecules (ADC). |
|
V5622 | SPDB crosslinker | 115088-06-7 | SPDB is useful heterobifunctional cross-linker, which is widely used to conjugate a small molecule drug to a targeted carrier (such as antibody, enzyme, protein and polymer). |
|
V54543 | SPDB-sulfo | 1628113-16-5 | SPDB-sulfo is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare antibody-conjugated active molecules (ADC). |
|
V54503 | SPDH | 1824718-79-7 | SPDH is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized in study/research of cancer or B cell proliferative diseases. |
|
V54521 | SPDMB | 2101206-29-3 | SPDMB is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare antibody-conjugated active molecules (ADC). |
|
V53057 | SPDMV | 890409-85-5 | SPDMV is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare antibody-conjugated active molecules (ADC). |
|
V54562 | SPDMV-sulfo | 2101206-86-2 | SPDMV-sulfo is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare antibody-conjugated active molecules (ADC). |
|
V52673 | SPDP-sulfo | 121115-30-8 | SPDP-sulfo is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized to prepare antibody-conjugated active molecules (ADC). |
|
V52921 | SPDV | 317331-86-5 | SPDV is a cleavable (degradable) ADC (Antibody-drug conjugate) linker that may be utilized in study/research of cancer or B cell growth/proliferation diseases. |
|
V53280 | Spermine(N3BBB) | 1190203-80-5 | Spermine(N3BBB) is an azide-bearing reagent for click chemistry that may be utilized in a variety of biochemical studies. |
|
V93187 | STI-8811 drug-linker | 2833733-13-2 | STI-8811 Drug Linker is a linker that can be used to synthesize the ADC molecule STI-8811. |
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