Histone Methyltransferase

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Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Histone Methyltransferase

Histone modifications are essential for controlling both overall gene expression and stage-specific gene expression. While histones H3K9 and H3K27 are typically associated with gene repression, methylation on histones H3K4, H3K36, and H3K79 is typically associated with gene activation. Site-specific methyltransferases and demethylases dynamically control the methylation of histone lysines. The methylation of H3K27 in cells is carried out by EZH2 (the catalytic subunit of PRC2).
Inhibiting DOT1L, a histone H3 lysine 79 methyltransferase, improves the production of induced pluripotent stem cells (iPSCs). A powerful and specific DOT1L inhibitor, EPZ-5676.

The histone methyltransferase enhancer of zeste homolog 2 (EZH2) trimethylates histone 3's lysine 27 (H3K27me3), which results in chromatin condensation and transcriptional repression and is essential for PRC2 activity.

Histone Methyltransferase related products

Cat No.	Product Name	CAS No.	Product Description
V3453	UNC0321	1238673-32-9	UNC0321 (UNC-0321) is a novel, potent and selective G9a histone methyltransferaseinhibitor with anticancer activity.
V0392	UNC0379	1620401-82-2	UNC0379 is a substrate competitive lysine methyltransferase SETD8 (KMT5A) inhibitorwith antineoplastic activity.
V0395	UNC0631	1320288-19-4	UNC0631 (UNC-0631) is a potent and selective inhibitor of histone methyltransferase G9a (KMT1C; EHMT2, IC50 = 4 nM)with antineoplastic activity.
V2603	UNC0638	1255580-76-7	UNC0638 (UNC-0638) is a selective and cell-permeable inhibitor of G9a histone methyltransferaseand GLP with IC50 of<15 nM and 19 nM, respectively.
V3137	UNC0642	1481677-78-4	UNC0642 (UNC-0642) is a novel, potent, selective, dual inhibitor ofG9a/GLP (histone methyltransferases) with antitumor activity.
V2057	UNC0646	1320288-17-2	UNC0646 is a novel, potent and selective histone methyltransferase G9a inhibitor with IC50 of 6 nM.
V0385	UNC1999	1431612-23-5	UNC1999 (UNC-1999) is an orally bioavailable, cell-permeable, selective, SAM-competitive and dual inhibitor of EZH2/EZH1 (Enhancer of zeste homolog) with antineoplastic activity.
V35160	UNC2399	2412791-72-9	UNC2399, a biotinylated UNC1999, is a selective EZH2 inhibitor (antagonist) with high in vitro potency against EZH2 with IC50 of 17 nM.
V2605	UNC3866	1872382-47-2	UNC3866 is a novel and potent antagonist of the methyllysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains with Kd of 100 nM as determined by AlphaScreen.
V94308	UNC3866 TFA	1872382-48-3	UNC3866 TFA is a potent CBX7-H3 antagonist with IC50 of 66±1.2 nM.
V75864	UNC4976	2920299-34-7	UNC4976 is a nucleic acid-binding PAM (positive allosteric modulator) peptidomimetic of the CBX7 chromatin domain.
V76388	UNC4976 TFA		UNC4976 TFA is a nucleic acid-binding PAM (positive allosteric modulator) peptidomimetic of the CBX7 chromatin domain.
V40758	UNC6852		UNC6852 is a selective PRC2 degrader based on PROTAC technology.
V35159	UNC6852	2688842-08-0	UNC6852 is a selective PRC2 degrader based on PROTAC technology.
V53045	UNC6934	2561494-77-5	UNC6934 is a chemical probe targeting the PWWP domain of NSD2, which localizes to the nucleolus.
V103441	UNC7145	2561494-78-6	UNC7145 is an inactive derivative of UNC6934 and serves as a negative control for the protein-protein inhibitory activity of UNC6934.
V93789	UNC8153	2929304-60-7	UNC8153 is a potent and selective nuclear receptor-binding SET domain 2 (NSD2) targeted degrader with Kd of 24 nM.
V75870	UNC8153 TFA	2929304-61-8	UNC8153 TFA is a potent and specific nuclear receptor binding SET domain-containing 2 (NSD2) targeted degrader with a Kd of 24 nM.
V50975	UZH2	2756566-45-5	UZH2 is a potent and specific METTL3 inhibitor (antagonist) with IC50 of 5 nM.
V97159	W4275	3051650-00-8	W4275 (Compound 42) is an orally active and selective NSD2 inhibitor with IC50 of 17 nM.