Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V4577 | Udenafil | 268203-93-6 | Udenafil (formerly known as DA8159) isa novel and potent PDE5 inhibitor used in urology to treat erectile dysfunction. |
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V2647 | Vardenafil | 224785-90-4 | Vardenafil (also known as BAY 38-9456; trade names: Levitra; Staxyn; Vivanza)is a novel and potent PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. |
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V0781 | Vardenafil HCl Trihydrate | 330808-88-3 | Vardenafil HCl Trihydrate (formerly also known as BAY 38-9456, trade names Levitra; Staxyn; Vivanza) is an approved medication acting as aphosphodiesterase/PDE inhibitor with important biological activity. |
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V3099 | Ziritaxestat (GLPG-1690) | 1628260-79-6 | Ziritaxestat (formerly GLPG1690) is a potent and a first-in-class selective autotaxin (ATX)inhibitor (IC50 = 131 nM andKiof 15 nM) with the potential to be used in the treatment of idiopathic pulmonary disease (IPF). |
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