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Proteasome

Proteasome

Proteasomes are enormous protein complexes found in all eukaryotes, archaea, and some bacteria. They are found in the cytoplasm and nucleus of eukaryotes. The proteasome's primary job is to break down unwanted or damaged proteins through the process of proteolysis, which is a peptide bond-breaking chemical reaction. Proteases are enzymes that carry out these types of reactions.A key mechanism by which cells control the concentration of specific proteins and destroy improperly folded proteins includes proteasomes. When a protein is degraded, it produces peptides that are seven to eight amino acids long. These peptides can then be further broken down into amino acids and used to create new proteins. A tiny protein called ubiquitin marks proteins for degradation. The tagging process is sped up by ubiquitin ligases, an enzyme family. Once a protein has one ubiquitin molecule attached to it, other ligases know to attach more ubiquitin molecules. As a result, a polyubiquitin chain forms, which the proteasome binds to and uses to break down the tagged protein.

Proteasome related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Catechin 3-gallate V117747 (+)-Catechin 3-gallate 25615-05-8 (+)-Catechin-3-gallate is an orally effective polyphenol compound and a non-selective proteasome inhibitor.
20S Proteasome-IN-5 V87692 20S Proteasome-IN-5 20S Proteasome-IN-5 (Compound 5) is a macrocyclic inhibitor of 20S Proteasome with IC50 values of 0.19 and 52.5 μM for ChT-L and PGPH-L activities, respectively.
26S蛋白酶体抑制剂I V2424 26S proteasome inhibitor I 858557-69-4 20S Proteasome-IN-1 is a 26S proteasome inhibitor.
4-Nitrochalcone V126477 4-Nitrochalcone 1222-98-6 4-Nitrochalcone (2-(4-nitrobenzylidene)acetophenone) inhibits the proteasome and TNFα-induced NF-κB activity.
5-Amino-8-hydroxyquinoline (5A8HQ) V73372 5-Amino-8-hydroxyquinoline (5A8HQ) 13207-66-4 5-Amino-8-hydroxyquinoline (5A8HQ) is a potential anticancer candidate active molecule with good proteasome inhibitory activity
6-Chlorooxindole V111261 6-Chlorooxindole 56341-37-8 6-Chloroindolone (compound 2) is a selective chymotrypsin inhibitor with an IC50 value of 470 μM.
Ac-ANW-AMC V73376 Ac-ANW-AMC 2357123-49-8 Ac-ANW-AMC is a fluorescent substrate for immunoproteasome.
Ac-Leu-Leu-Norleucinol V73379 Ac-Leu-Leu-Norleucinol 148333-42-0 Ac-Leu-Leu-Norleucinol is a calpain inhibitor that may be utilized to study acute liver injury caused by Acetaminophen and can reduce induced levels of aspartate aminotransferase (ALT) and alanine aminotransferase (AST).
Ac-Nle-Pro-Nle-Asp-AMC V73366 Ac-Nle-Pro-Nle-Asp-AMC 355140-49-7 Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate of the 26S proteasome.
Ac-RLR-AMC V87691 Ac-RLR-AMC 929903-87-7 Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) is a fluorescent substrate for the 26S proteasome (Ex/Em: 380/440-460 nm).
Ac-RLR-AMC TFA V87690 Ac-RLR-AMC TFA Ac-RLR-AMC (Ac-Arg-Leu-Arg-AMC) TFA is a fluorescent substrate for the 26S proteasome (Ex/Em: 380/440-460 nm).
Acetyl-Calpastatin(184-210)(human) TFA V77743 Acetyl-Calpastatin(184-210)(human) TFA Acetyl-Calpastatin(184-210)(human) TFA is a specific and reversible calpain inhibitor (antagonist) with Kis of 0.2 nM and 6 μM for μ-calpain and cathepsin L respectively.
Acetyl-Calpastatin(184-210)(human), Negative Control V85691 Acetyl-Calpastatin(184-210)(human), Negative Control
Anticancer agent 114 V77981 Anticancer agent 114 Anticancer agent 114 is an orally bioavailable dipeptide boronate proteasome inhibitor (antagonist) with IC50 of 2.2 nM.
Anticancer agent 233 V89021 Anticancer agent 233 Anticancer agent 233 (compound 5g) is a 3,5-bis(arylmethylene)-4-piperidinone derivative with anticancer activity, with GI50 values of 0.25 and 0.23 μM for cervical cancer (HeLa) and colon cancer (HCT116) cell lines, respectively.
Argyrin A V129390 Argyrin A 174423-37-1 Argyrin A is a potent anti-tumor drug.
Argyrin B V129391 Argyrin B 174423-36-0 Argyrin B is a reversible, non-competitive immunoproteasome inhibitor.
ARI-3144 V84788 ARI-3144 1426305-25-0
Az-NC-002 V118625 Az-NC-002 1356828-49-3 Az-NC-002 is a proteasome trypsin-like site (β2) and immunoproteasome β2i specific active probe.
BC-05 V60269 BC-05 2260717-73-3 BC-05 is an orally bioactive and potent inhibitor of CD13 and proteasome.
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