Proteasomes are enormous protein complexes found in all eukaryotes, archaea, and some bacteria. They are found in the cytoplasm and nucleus of eukaryotes. The proteasome's primary job is to break down unwanted or damaged proteins through the process of proteolysis, which is a peptide bond-breaking chemical reaction. Proteases are enzymes that carry out these types of reactions.A key mechanism by which cells control the concentration of specific proteins and destroy improperly folded proteins includes proteasomes. When a protein is degraded, it produces peptides that are seven to eight amino acids long. These peptides can then be further broken down into amino acids and used to create new proteins. A tiny protein called ubiquitin marks proteins for degradation. The tagging process is sped up by ubiquitin ligases, an enzyme family. Once a protein has one ubiquitin molecule attached to it, other ligases know to attach more ubiquitin molecules. As a result, a polyubiquitin chain forms, which the proteasome binds to and uses to break down the tagged protein.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73380 | LU-002i | 1838705-22-8 | LU-002i is a subunit-selective inhibitor of proteases β2c and β2i, with IC50 of 220nM for β2i. |
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V73383 | MeOSuc-Gly-Leu-Phe-AMC | 201854-05-9 | MeOSuc-Gly-Leu-Phe-AMC is a bioactive peptide substrate of the proteasome. |
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V73390 | Neurodegenerative Disorder-Targeting Compound 1 | 1254698-39-9 | Neurodegenerative Disorder-Targeting Compound 1 is a calpain inhibitor. |
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V4810 | PD 150606 | 179528-45-1 | PD 150606 is novel, potent, selective, and cell-permeable non-peptide calpain inhibitor withKivalues of 0.21 μM and 0.37 μM for μ- and m-calpains respectively. |
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V73364 | PD 151746 | 181765-30-0 | PD151746 is a calpain inhibitor that can suppress u-calpain (Ki = 0.26 ± 0.03 μM) with 20 times higher selectivity than m-calpain (Ki = 5.33 ± 0.77μM). |
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V73374 | Proteasome β2c/i-IN-1 | 2322333-75-3 | Proteasome β2c/i-IN-1 (compound 37) is a subunit-selective inhibitor of the proteases β2c and β2i. |
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V73369 | Proteasome-IN-5 | 1613134-34-1 | Proteasome-IN-5 (compound 5) is a protease inhibitor. |
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V2175 | RAMB4 | 145888-79-5 | RAMB4 (PTP1B-IN-9) is a novel and potent ubiquitin-proteasome system (UPS)-stressor. |
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V81349 | Sadopeptins A | Sadopeptins A is a naturally occurring compound extracted from Streptomyces sp. | |
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V81350 | Sadopeptins B | Sadopeptins B is a naturally occurring compound extracted from Streptomyces sp. | |
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V73375 | Suc-Ala-Ala-Pro-Phe-SBzl | 80651-95-2 | Suc-Ala-Ala-Pro-Phe-SBzl works as a substrate for rat intestinal mast cell protease (RMCP I), rat skeletal muscle mast cell protease (RMCP II), and chymotrypsin (Chymotrypsin) . |
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V73385 | Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate; Z-ARR-AMC) | 90468-18-1 | Z-Ala-Arg-Arg-AMC (Fluorogenic Proteasome Substrate) is a fluorescent substrate used to measure the trypsin-like activity of the proteasome. |
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V73381 | Z-GGF-CMK | 35172-59-9 | Z-GGF-CMK is a protease inhibitor that can suppress ClpP1P2 and the proteasome. |
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V73386 | Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) | 159659-05-9 | Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde that works as a selective proteasomal inhibitor (for branched-chain amino acid (AA) preferential inhibition, Ki is 1.5 µM; Ki 2.3 µM for small neutral amino acid (AA)s; Ki 40.5 µM for chymotrypsin-like activity; IC50 3.1 µM for peptidyl-glutamyl peptide hydrolyzing activity). |
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V73384 | Z-Leu-Leu-Glu-AMC (Z-LLE-AMC) | 348086-66-8 | Z-Leu-Leu-Glu-AMC is a substrate peptide that may be utilized to measure the post-acid-like hydrolysis activity of the 20S proteasome |
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V73387 | Z-Leu-Leu-Glu-βNA (Z-Leu-Leu-Glu-β-naphthylamide) | 75873-85-7 | Z-Leu-Leu-Glu-βNA (Z-Leu-Leu-Glu-β-naphthylamide) is a substrate for the determination of 20S proteasome glutamyl peptide hydrolase activity. |
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V73389 | Z-Leu-Leu-Leu-AMC (Z-LLL-AMC) | 152015-61-7 | Z-Leu-Leu-Leu-AMC is a fluorogenic substrate peptide that may be utilized to measure the chymotrypsin-like protease activity of the 20S proteasome. |
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V73370 | Z-Leu-Leu-Tyr-COCHO | 204649-66-1 | Z-Leu-Leu-Tyr-COCHO is a potent inhibitor of chymotrypsin-like activity with Ki of 3.0 nM. |
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V73388 | Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) | 133429-58-0 | Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic protease complex (Ki = 460 nM). |
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V73365 | Zetomipzomib maleate (KZR-616 maleate) | 2170983-62-5 | Zetomipzomib (KZR-616) maleate is a first-in-class immunoproteasome inhibitor that selectively targets the immunoproteasome subunits LMP7 (IC50= 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50= 131/179 nM =hLMP2/mLMP2). |
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