Phospholipase is one of a very complex group of enzymes that converts phospholipids into fatty acids and other compounds. The enzymatic reaction that phospholipases catalyze serves to define them. Phospholipase A, which has members A1 and A2, Phospholipase B, which can perform both A1 and A2 reactions, Phospholipase C, and Phospholipase D are the classes.
Fatty acids and lysophospholipids are produced when phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of glycerophospholipids. Phospholipase C (PLC) transforms inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) from phosphatidylinositol 4,5-bisphosphate (PIP2). DAG and IP3 each regulate a variety of cellular processes and serve as a starting point for the creation of additional significant signaling molecules. PLC serves as the hub of numerous significant interconnected regulatory networks. The production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes like membrane trafficking, actin cytoskeleton remodeling, cell proliferation, and cell survival, is carried out by the crucial enzyme phospholipase D (PLD).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73554 | SB-435495 ditartrate | 304694-43-7 | SB-435495 ditartrate is a potent, selective, reversible, non-covalent, orally bioactive Lp-PLA2 inhibitor (antagonist) with IC50 of 0.06 nM. |
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V73553 | SB-435495 hydrochloride | 304694-41-5 | SB-435495 HCl is a potent, selective, reversible, non-covalent, orally bioactive Lp-PLA2 inhibitor (antagonist) with IC50 of 0.06 nM. |
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V73533 | Sphingomyelin phosphodiesterase (sphingomyelin phosphodiesterase) | 9031-54-3 | Sphingomyelin phosphodiesterase is a hydrolase involved in sphingomyelin metabolism. |
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V2316 | Tris(2,4-di-tert-butylphenyl)phosphate | 95906-11-9 | Tris(2,4-di-tert-butylphenyl)phosphate is a bioactive compound extracted from Vitex negundo L. |
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V5094 | U-73343 | 142878-12-4 | U-73343 is a novel inhibitor of PLC (phospholipase C)-dependent processes and an analogue of U-73122. |
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V27947 | Varespladib Methyl | 172733-08-3 | Varespladib Methyl (LY-333013;A-002; S-3013)is a novel and potent sPLA2 (secretory phospholipase A2) inhibitorwith the potential for treating acute coronary syndrome (ACS). |
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V73527 | VU0364739 | 1244639-78-8 | VU0364739 is a selective PLD2 inhibitor (IC50= 22 nM). |
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V73535 | WH-15 | 1264748-47-1 | WH-15 is a fluorescent PLC reporter gene with Km values of 49, 30 and 86.1 μM for PLC-γ1, PLC-δ1 and PLC-β2 respectively. |
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