Phosphatases are enzymes that strip a protein of its phosphate group. PTPs (protein tyrosine phosphatases) are a large family of cytoplasmic and transmembrane enzymes. PTPs are crucial in maintaining the integrity of cell-cell and cell-matrix contacts as well as controlling the proliferative activity of cells. PTP1B, a non-receptor PTP, is frequently found in the endoplasmic reticulum and in vesicles that are close to the plasma membrane.PTP1B has been a popular therapeutic target for the management of type 2 diabetes mellitus and obesity due to its important role as a negative regulator of leptin receptor pathways. Animal cell cytoplasm contains four major serine/threonine-specific protein phosphatase catalytic subunits. While PP2C seems to be different from the other two, PP1, PP2A, and PP2B, all three of these enzymes are members of the same gene family. A diverse group of enzymes known as alkaline phosphatases is found in abundance in mammalian cells. Following the general equation, acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V81256 | PVD-06 | PVD-06 is a selective PTPN2 degrader (PTPN2/PTP1B selectivity index >60-fold), inducing PTPN2 degradation in a ubiquitination- and proteasome-dependent manner. | |
|
V31912 | Raphin1 | 2022961-17-5 | Raphin1 is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). |
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V31468 | Raphin1 acetate | 2242616-04-0 | Raphin1 acetate is an orally bioavailable, selective inhibitor of the regulatory phosphatase PPP1R15B (R15B). |
|
V69761 | RMC-3943 | 1801764-60-2 | RMC-3943 is an allosteric SHP2 inhibitor (IC50 for full-length inhibition is 2.19 nM). |
|
V1947 | Sal003 | 1164470-53-4 | Sal003 is a potent, selective and cell-permeable eIF-2α phosphatase inhibitor. |
|
V69153 | SC-43 | 1400989-25-4 | SC-43, an analogue of Sorafenib, is a potent orally bioactive SHP-1 (PTPN6) agonist. |
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V69740 | SHP099 monohydrochloride | 2200214-93-1 | SHP099 HCl is a potent, selective, orally bioactive SHP2 inhibitor (antagonist) with IC50 of 70 nM. |
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V69754 | SHP2 inhibitor LY6 (LY6) | 2296718-09-5 | SHP2 inhibitor LY6 (LY6) is a potent and specific SHP2 inhibitor (antagonist) with IC50 of 9.8 µM. |
|
V88066 | SHP2-IN-25 | SHP2-IN-25 (Compound 6) is a SHP2 allosteric inhibitor with IC50 of 225 nM. | |
|
V87662 | SHP2-IN-26 | SHP2-IN-26 (Compound 4b) is a highly selective allosteric inhibitor of SHP2 with IC50 of 3.2 nM. | |
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V88067 | SHP2-IN-29 | 2130080-86-1 | SHP2-IN-29 (Compound 3) is a potent SHP2 inhibitor with IC50 of 0.18 μM. |
|
V69760 | SHP2/CDK4-IN-1 | 2924036-87-1 | SHP2/CDK4-IN-1 (compound 10) is an orally bioavailable dual (bifunctional) inhibitor of SHP2 and CDK4 with IC50 of 4.3 and 18.2 nM, respectively. |
|
V99744 | Sipuleucel-T | 917381-47-6 | Sipuleucel-T is a cancer vaccine that recognizes prostatic acid phosphatase (PAP), presents PAP antigens, and stimulates an immune response against prostate cancer cells. |
|
V32196 | SMAP-2 | 1809068-70-9 | SMAP-2 (DT-1154;SMAP 2; DT1154;SMAP2;DT 1154) is a novel, potent and orally bioavailable phosphatase 2A (PP2A) activator with potential anticancer activity. |
|
V73331 | Sophoraisoflavone A (Allolicoisoflavone B) | 117204-81-6 | Sophoraisoflavone A (Allolicoisoflavone B) is a naturally occurring compound extracted from Glycyrrhiza inflate. |
|
V73308 | SPAA-52 | 2837000-75-4 | SPAA-52 is an orally bioactive, competitive and reversible low molecular weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50=4 nM, Ki=1.2 nM). |
|
V81448 | Stevisalioside A | 142934-44-9 | Stevisalioside A (Compound 2) can be extracted from stevia root. |
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V81449 | Stevisaliosides D | Stevisaliosides D (Compound 5) can be extracted from stevia root. | |
|
V87663 | Sydowimide A | Sydowimide A is a potent inhibitor of Src homology 2 domain-containing phosphatase 1 (SHP1), T-cell protein tyrosine phosphatase (TCPTP), and leukocyte common antigen (CD45), with IC50 values of 1.5, 2.4, and 18.83 μM, respectively. | |
|
V3399 | TCS 401 | 243966-09-8 | TCS-401 HCI is a novel, potent and selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B)with Ki of 0.29 µM. |
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