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Mitochondrial Metabolism

Mitochondrial Metabolism

Mitochondria use multiple carbon fuels to produce ATP and metabolites, including pyruvate, which is generated from glycolysis; amino acids such as glutamine; and fatty acids. The reducing equivalents NADH and FADH2, which transfer their electrons to the electron transport chain, are produced by these carbon fuels by feeding into the TCA cycle in the mitochondrial matrix. Complex organelles called mitochondria are crucial for many aspects of cellular function, including metabolism, immune control, and cell death.Calcium buffering, lipid flux, and intracellular signaling are just a few of the many cellular processes and molecular interactions that mitochondria actively participate in. It is becoming more widely acknowledged that mitochondrial dysfunction is a defining feature of many diseases, including cancer, cardiovascular, and neurodegenerative conditions. Mitochondrial metabolism influences processes like the epithelial-to-mesenchymal transition, which is a key factor in the progression of tumors. The epigenetic landscape is altered by mitochondrial metabolism and the oncometabolites that result to change the aggressiveness characteristics of cancer cells. Regarding the survival of tumors in response to treatment, changes in mitochondrial metabolism are important.

Mitochondrial Metabolism related products

Structure Cat No. Product Name CAS No. Product Description
(+)-trans-C75 V101130 (+)-trans-C75 1234694-20-2 (+)-trans-C75 ((+)-C75) is the enantiomer of C75, a fatty acid synthase inhibitor.
(3S,4R)-ME-344 V119069 (3S,4R)-ME-344 1374524-84-1 (3S,4R)-ME-344 is the (3S,4R)-enantiomer of ME-344.
(E/Z)-MitoTam iodide, hydriodide V121806 (E/Z)-MitoTam iodide, hydriodide (E/Z)-MitoTam iodide, hydriodide is an E/Z mixture of MitoTam iodide and hydriodide.
(Z)-NMac1 V122305 (Z)-NMac1 1667730-59-7 (Z)-NMac1 is an Nm23-H1 activator found in ginger (Zingiber cassumunar Roxb.).
1-Methoxycyclopropanecarboxylic acid V106747 1-Methoxycyclopropanecarboxylic acid 100683-08-7 1-Methoxycyclopropanecarboxylic acid is an uncoupler that stimulates respiration to approximately 160% of baseline levels.
13′-Hydroxy-δ-tocopherol V123156 13′-Hydroxy-δ-tocopherol 1308347-24-1 13′-Hydroxy-δ-tocopherol is a metabolite of long-chain vitamin E.
17β-HSD10-IN-4 V123383 17β-HSD10-IN-4 17β-HSD10-IN-4 is a selective brain-penetrating 17β-HSD10 inhibitor with an IC50 value of 6.33 μM.
5-[[4-[2-(3-甲氧基苯基)-2-氧代乙氧基]苯基]甲基]-2,4-噻唑烷二酮 V9679 MSDC-0602 1133819-87-0 MSDC-0602 is an insulin sensitizer potentially for the treatment of diabetes (metabolic modulator).
5-Amino-6-(5-phospho-D-ribitylamino)uracil V109648 5-Amino-6-(5-phospho-D-ribitylamino)uracil 71491-01-5 5-Amino-6-(5-phosphate-D-ribosylamino)uracil (5-amino-6-(5′-phosphate-ribosylamino)uracil) is a substance that can enhance oxidative phosphorylation or mitochondrial respiration.
8-OAc V87604 8-OAc 2550395-87-2 8-OAc is a potent and selective inhibitor of mitochondrial electron transport chain (ETC) complex I.
Ac-MtFluNox V128203 Ac-MtFluNox
AK-4 V104870 AK-4 AK-4 is a glucose-lowering agent that acts as a mitochondrial uncoupler.
ALK/PI3K/AKT-IN-1 V128532 ALK/PI3K/AKT-IN-1 3050831-84-7 ALK/PI3K/AKT-IN-1 (compound 45) inhibited the proliferation of A549, H1975 and PC9 cancer cells, with IC50 values of 0.44, 0.83 and 1.51 μM, respectively.
Anticancer agent 320 V128992 Anticancer agent 320 Anticancer agent 320 is a potent, broad-spectrum anticancer drug with low toxicity to non-cancer cells.
Apoptosis inducer 59 V129296 Apoptosis inducer 59 Apoptosis inducer 59 is a camphor sulfonamide thiazole hydrazone derivative with antitumor activity.
Bac-429 V104842 Bac-429 2227449-70-7 Bac-429 (compound 23) is an N-acyl amino acid analog that stimulates mitochondrial respiration.
BBOX-IN-1 V129923 BBOX-IN-1 3106496-37-8 BBOX-IN-1 is a potent BBOX inhibitor with an IC50 of 0.02 μM.
BE2647 V105149 BE2647 BE2647 is a selective mitochondrial pyruvate carrier (MPC) inhibitor with EC50 of 70 nM.
Bevemipretide trihydrochloride V130106 Bevemipretide trihydrochloride 2589640-11-7 Bevemipretide trihydrochloride is a mitochondrial function repair agent that can cross the blood-brain barrier.
BI-6C9 V4719 BI-6C9 791835-21-7 BI-6C9 is a novel and potent inhibitor of BH3 interacting domain (Bid) with Kd of 20 µM, it acts by preventing mitochondrial outer membrane potential (MOMP) and mitochondrial fission, and protecting the cells from cell death.
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