HIFs (Hypoxia-inducible factors) are transcription factors that react to variations in the amount of oxygen available to cells, more specifically, to reductions in oxygen, or hypoxia. The effects of hypoxia, a condition of low oxygen concentration, on the cell are mediated by the HIF signaling cascade. Oftentimes, hypoxia prevents cells from differentiating. However, hypoxia encourages the growth of blood vessels and is crucial for the development of a vascular system in both cancer tumors and embryos.Additionally, the hypoxia in wounds encourages keratinocyte migration and epithelium repair. HIFs are essential to development in general. HIF-1 gene deletion in mammals causes perinatal death. It has been demonstrated that HIF-1 is essential for chondrocyte survival and enables the cells to adapt to low oxygen environments in the growth plates of bones. Human metabolism is controlled in large part by HIF. A number of medications that function as selective HIF prolyl hydroxylase inhibitors have recently been created.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V104413 | PROTAC HIF-1α degrader-1 | PROTAC HIF-1α Degrader-1 (Compound V2) is a potent hypoxia-inducible factor-1α (HIF-1α) PROTAC degrader with an IC50 value of 7.54 µM. | |
|
V113324 | PROTAC HIF-1α degrader-2 | 3095636-64-6 | PROTAC HIF-1α Degrader-2 is a highly efficient and selective PROTAC degrader that targets HIF-1α. |
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V4090 | PT-2385 | 1672665-49-4 | PT2385 (PT-2385) is a nove, potent, selective and orally bioactive inhibitor of hypoxia inducible factor (HIF-2α) with anticancer and anti-hepatic steatosis activity. |
|
V51623 | TAT-cyclo-CLLFVY | 1446322-66-2 | TAT-cyclo-CLLFVY is a HIF-1 heterodimeric cyclic peptide conjugate that can inhibit regulatory hypoxia signaling activation. |
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V81522 | TAT-cyclo-CLLFVY TFA | TAT-cyclo-CLLFVY TFA is a cyclic peptide inhibitor of HIF-1 heterodimerization that can inhibit hypoxia signaling in cancer cells. | |
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V88914 | Teleocidin B-4 | 11032-05-6 | Teleocidin B-4 is a PKC activator. |
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V51621 | TRC-160334 | 1293289-69-6 | TRC160334 is a hypoxia-inducible factor (HIF) hydroxylase inhibitor. |
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V94259 | TRC160334 sodium | 1293290-41-1 | TRC160334 sodium is a hypoxia-inducible factor (HIF) hydroxylase inhibitor. |
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V51624 | Verucopeptin | 138067-14-8 | Verucopeptin is a potent activator of HIF-1 (IC50=0.22 μM) and can reduce the expression of HIF-1 target genes and the expression level of HIF-1α. |
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V51004 | WAY-325641 | 869354-47-2 | HIV-1 integrase inhibitor |
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V103259 | ZG-2033 | 2685739-28-8 | ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity in a luciferase reporter assay (EC50 = 490 nM). |
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V89017 | ZG-2291 | 2962103-40-6 | ZG-2291 is a selective inhibitor targeting FIH (hypoxia inducible factor inhibitor) and is orally active. |
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V94304 | ZG-2305 | 2962103-54-2 | ZG-2305 is a potent, selective, and orally available hypoxia-inducible factor (FIH) inhibitor with Ki values of 79.6 and 2786 nM for FIH and PHD2, respectively. |
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V111003 | ZG-2686 | 1795110-22-3 | ZG-2686 is a highly potent and selective HIF-2α agonist with an EC50 of 0.25 µM. |
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V73833 | Zifcasiran sodium (ADS-007 sodium; ARO HIF2 sodium) | 2437257-12-8 | Zifcasiran sodium is a hypoxia-inducible factor (HIF) synthesis inhibitor and displays anti-tumor activity and may be utilized in the study of advanced renal cell carcinoma. |
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V5246 | Vadadustat (PG-1016548; AKB-6548) | 1000025-07-9 | Vadadustat (formerly AKB-6548;PG-1016548; B-506;AKB6548;PG1016548;Vafseo) is a novel, potent, titratable and orally bioavailable hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor with the potential for the treatment of anemia. |
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V20522 | Enarodustat (JTZ951) | 1262132-81-9 | Enarodustat (formerly JTZ-951; JTZ951;Enaroy) is an orally bioactive hypoxia inducible factor-proly hydroxylase (HIF-PH) inhibitorapproved (in 2020) in Japan for the treatment of anemia associated with chronic kidney disease (CKD). |
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V30464 | Oroxylin A | 480-11-5 | Oroxylin A is an active flavonoid compound with strong anti-cancer effects. |
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V51630 | Dimethyl-bisphenol A | 1568-83-8 | Dimethyl-bisphenol A (DMBPA) is a potent HIF-1α inhibitor. |
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V51639 | Moracin O | 123702-97-6 | Moracin O comes from Morus alba Linn. |
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