| Size | Price | Stock | Qty |
|---|---|---|---|
| 100mg |
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| 500mg |
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| Targets |
Dimethyl-bisphenol A targets hypoxia-inducible factor-1α (HIF-1α), a transcription factor that mediates cellular responses to hypoxia. By inhibiting HIF-1α, Dimethyl-bisphenol A reduces the expression of HIF-1 target genes such as Vegfa (VEGF). It is a structural analog of bisphenol A (BPA) and is used in toxicology research.
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|---|---|
| ln Vitro |
In big osteoclasts (OC), the expression of Vegfa120 and Vegfa164 is strongly inhibited by dimethylbisphenol A (DMBPA; 50 μM; 30 minutes) [1].
In vitro, Dimethyl-bisphenol A is a potent HIF-1α inhibitor. It reduces Vegfa mRNA expression. As a structural analog of bisphenol A, it is used as a model compound for studying endocrine disruption, receptor binding, and metabolic pathways associated with bisphenols. |
| ln Vivo |
In vivo data for Dimethyl-bisphenol A is not extensively reported in publicly available sources. As a HIF-1α inhibitor and BPA analog, the compound has potential applications in animal models of cancer and endocrine disruption. By inhibiting HIF-1α and VEGF expression, Dimethyl-bisphenol A could suppress angiogenesis and tumor growth. However, specific published in vivo efficacy studies are not detailed in the current literature.
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| Enzyme Assay |
The in vitro HIF-1α inhibition assay for Dimethyl-bisphenol A uses cells transfected with a HIF-1 reporter gene. Cells are treated with varying concentrations of Dimethyl-bisphenol A under hypoxic conditions, and reporter gene activity is measured. Vegfa mRNA expression is measured by qPCR. HIF-1α protein levels are measured by Western blotting.
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| Cell Assay |
Cellular assays for Dimethyl-bisphenol A are conducted in various cell lines. Cells are treated with varying concentrations of Dimethyl-bisphenol A. HIF-1α protein levels are measured by Western blotting. Vegfa mRNA expression is measured by qPCR. Cell proliferation and viability are measured using standard assays such as MTT or CellTiter-Glo. The compound's effects on endocrine signaling are assessed.
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| Animal Protocol |
In vivo studies for Dimethyl-bisphenol A would typically involve animal models of cancer or endocrine disruption. The compound would be administered via oral or intraperitoneal routes. Efficacy would be assessed by measuring tumor growth, angiogenesis, or endocrine parameters. However, specific published in vivo protocols for Dimethyl-bisphenol A are not available in the current literature.
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| ADME/Pharmacokinetics |
Pharmacokinetic data for Dimethyl-bisphenol A is not extensively reported. The compound has a molecular weight of 256.34 g/mol and a molecular formula of C17H20O2. It has a CAS number of 1568-83-8. As a small molecule, it is expected to have moderate bioavailability. Detailed PK parameters such as half-life and bioavailability are not available.
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| Toxicity/Toxicokinetics |
Toxicity data for Dimethyl-bisphenol A is derived from its use as a BPA analog. As with BPA, it may have endocrine-disrupting effects. As a research compound, Dimethyl-bisphenol A is intended for research use only and not for human therapeutic applications. Standard in vitro cytotoxicity assays and in vivo toxicology studies would be required for a complete toxicity assessment.
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| References | |
| Additional Infomation |
Dimethyl-bisphenol A (DMBPA; CAS 1568-83-8) is a potent HIF-1α inhibitor. It reduces Vegfa mRNA expression. It has a molecular formula of C17H20O2 and a molecular weight of 256.34 g/mol. Dimethyl-bisphenol A is a synthetic derivative of bisphenol A used in research. It is for research use only.
|
| Molecular Formula |
C17H20O2
|
|---|---|
| Molecular Weight |
256.34
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| Exact Mass |
256.146
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| CAS # |
1568-83-8
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| PubChem CID |
617780
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| Appearance |
White to off-white solid powder
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| Density |
1.022g/cm3
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| Boiling Point |
364.8ºC at 760 mmHg
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| Melting Point |
54-59ºC
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| Flash Point |
136.3ºC
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| Vapour Pressure |
3.45E-05mmHg at 25°C
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| Index of Refraction |
1.532
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| LogP |
4.029
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
2
|
| Rotatable Bond Count |
4
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| Heavy Atom Count |
19
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| Complexity |
232
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| Defined Atom Stereocenter Count |
0
|
| InChi Key |
OJYIBEYSBXIQOP-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C17H20O2/c1-17(2,13-5-9-15(18-3)10-6-13)14-7-11-16(19-4)12-8-14/h5-12H,1-4H3
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| Chemical Name |
1-methoxy-4-[2-(4-methoxyphenyl)propan-2-yl]benzene
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~390.11 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.75 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (9.75 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.9011 mL | 19.5053 mL | 39.0107 mL | |
| 5 mM | 0.7802 mL | 3.9011 mL | 7.8021 mL | |
| 10 mM | 0.3901 mL | 1.9505 mL | 3.9011 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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