The farnesoid X receptor (FXR) is a nuclear receptor superfamily member and ligand-activated transcription factor. By binding to DNA as a monomer or a heterodimer with the common NR partner, retinoid x receptor (RXR), to FXR response elements, FXR controls the expression of numerous genes. The FXR and FXR genes are the two recognized FXR genes.
FXR is primarily expressed in the liver and small intestine, where it is critical for the metabolism of bile acids, lipids, and glucose. FXR regulates bile acid (BA) synthesis and homeostasis, glucose and lipid metabolism, as well as playing a significant role in intestinal bacterial growth and liver regeneration through its specific target genes.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V121577 | (3α,5β,6β,7α)-BAR501 | 1632118-70-7 | (3α,5β,6β,7α)-BAR501 is a compound with a cholan skeleton and the molecular formula (3α, 5β, 6β, 7α)-BAR501. It can be used in the study of FXR and TGR5/GPBAR1-mediated diseases. |
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V85288 | (E)-GW 4064 | 1089660-72-9 | |
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V108742 | 2-Oxokolavenol | 130395-82-3 | 2-O-clavulanic acid is a selective farnesoid X receptor (FXR) agonist with an EC50 of approximately 3.7 μM. |
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V127223 | 5β-Cholane | 80373-86-0 | 5β-Cholane is a farnesoid X receptor (FXR) activator. |
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V1844 | Obeticholic Acid (6-ECDCA; INT-747) | 459789-99-2 | Obeticholic Acid (INT747; 6-ECDCA; 6-Ethylchenodeoxycholic acid; trade name Ocaliva), a novel derivative of cholic acid, is a potent,orally bioactive and selectiveagonist of farnesoid X receptor (FXR) with EC50 of 99 nM, and has anticholeretic and anti-inflammatory activities. |
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V74026 | Alismanol M | 2408810-59-1 | Alismanol M is an agonist of farnesoid X receptor (FXR) with EC50 of 50.25 μM. |
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V94855 | BAR-2227 | 2409154-23-8 | BAR-2227 (compound 3a) is a FXR agonist and LIFR inhibitor. |
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V107203 | Chenodeoxycholic acid 24-acyl-β-D-glucuronide | 208038-27-1 | Chenodeoxycholic acid 24-acyl-β-D-glucuronide is a metabolite of chenodeoxycholic acid. |
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V131483 | Chenodeoxycholic acid 24-acyl-β-D-glucuronide-d5 sodium | Chenodeoxycholic acid 24-acyl-β-D-glucuronide-d5 sodium is a deuterated sodium chenodeoxycholic acid 24-acyl-β-D-glucuronide. | |
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V107201 | Chenodeoxycholic acid 3-glucuronide | 58814-71-4 | Chenodeoxycholic acid 3-glucuronide is a metabolite of chenodeoxycholic acid, which can activate key nuclear receptors (FXR) with an EC50 of 8 μM and an EC50 of 11 μM for FXR activation in HEK293T cells. |
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V131649 | Cholic acid 3-O-glucuronide disodium | 59274-69-0 | Cholic acid 3-O-glucuronide disodium is a farnesoid X receptor (FXR) agonist with an EC50 value of 91.5 μM. |
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V18332 | Cilofexor | 1418274-28-8 | Cilofexor, formerly known as GS-9674, is a farnesoid X receptor (FXR) agonist. |
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V94323 | Cilofexor tromethamine | 2253764-93-9 | Cilofexor tromethamine (GS-9674 tromethamine) is a nonsteroidal oxidized farnesene receptor agonist with activity in improving markers of cholestasis and liver injury. |
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V133185 | Danifexor | 2648738-68-3 | Danifexor is an agonist of the farnesoid X receptor. |
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V109415 | Deoxycholic acid 3-O-β-D-glucuronide disodium | 59274-67-8 | Deoxycholic acid 3-O-β-D-glucuronide disodium salt is a bile acid receptor (FXR) agonist. |
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V133999 | DM175 | 832119-34-3 | DM175 is a partial agonist of FXR. |
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V118363 | dual FXR/PPARδ agonist-2 | Dual FXR/PPARδ agonist-2 is a dual FXR/PPARδ agonist produced by hybridizing FXR agonist GW-4064 and PPARδ agonist GW-0742. | |
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V135513 | F44-S101 | 3124701-00-1 | F44-S101 is an orally effective, potent, selective intestinal-restricting FXR antagonist with an IC50 value of 0.48 μM and lipid-lowering activity. |
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V74025 | Fargesone A | 116424-69-2 | Fargesone A is a potent and specific FXR agonist. |
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V104307 | FXR agonist 10 | FXR agonist 10 (Compound 27) is an agonist of FXR with an EC50 of 14.26 μM. |
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