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E1 E2 E3 Enzyme

E1 E2 E3 Enzyme

A protein modifier called ubiquitin (UB) controls a variety of vital cellular functions. The E1 enzyme activates UB's C-terminal carboxylate to start the process of UB's transfer through the E1-E2-E3 cascade onto target proteins. The ubiquitin is attached to the E1 enzyme by a thioester bond during an ATP-dependent reaction, and this enzyme serves as the activating enzyme. The ubiquitin is transferred from the E1 enzyme to the conjugating E2 enzyme. The E3 enzyme, also known as the ubiquitin ligase, catalyzes the transfer of ubiquitin to the target protein (also known as the substrate) by forming an isopeptide bond.

E1 E2 E3 Enzyme related products

Structure Cat No. Product Name CAS No. Product Description
Cbl-b-IN-18 V87389 Cbl-b-IN-18 Cbl-b-IN-18 (compound 51) is an inhibitor of the E3 ubiquitin ligase Cbl-b, inhibiting Cbl-b phosphorylation (IC50< 100 nM).
Cbl-b-IN-19 V87390 Cbl-b-IN-19 Cbl-b-IN-19 (Compound 49) is an inhibitor of the RING finger E3 ligase Cbl-b, inhibits Cbl-b phosphorylation with IC50 < 100 nM.
Cbl-b-IN-20 V87392 Cbl-b-IN-20 Cbl-b-IN-20 (Example 50) is a casitas B-lineage lymphoma oncogene-b (Cbl-b) inhibitor with IC50 value <100 nM.
Cbl-b-IN-26 V98538 Cbl-b-IN-26 3035443-17-2 Cbl-b-IN-26 (Example A1) is an inhibitor of Cbl-b with a Kd of 34.6 nM.
Cbl-b-IN-29 V111015 Cbl-b-IN-29 3070411-10-5 Cbl-b-IN-29 is an orally effective CBL-B inhibitor.
Cbl-b-IN-30 V110977 Cbl-b-IN-30 Cbl-b-IN-30 is an orally effective inhibitor of Castatus B-cell lymphoma-b (CBLB).
Cbl-b-IN-31 V109162 Cbl-b-IN-31 3029912-63-5 Cbl-b-IN-31 (compound Pep 1) is a Cbl-b inhibitor with a Kd value of 0.42 μM.
Cbl-b-IN-32 V131168 Cbl-b-IN-32 Cbl-b-IN-32 is a Cbl-b inhibitor with an IC50 of 6.83 μM.
Cbl-b-IN-6 V73103 Cbl-b-IN-6 2815221-33-9 Cbl-b-IN-6 (Compound 246) is an inhibitor (blocker/antagonist) of casitas b lineage lymphoma (Cbl-b) and c-Cbl? with IC50 of 5.8 nM and 4.4 nM respectively.
Cbl-b-IN-7 V73104 Cbl-b-IN-7 2815221-35-1 Cbl-b-IN-7 (Compound 248) is an inhibitor (blocker/antagonist) of casitas b lineage lymphoma (Cbl-b) and c-Cbl? with IC50 of 6.7 nM and 5.2 nM respectively.
Cbl-b-IN-8 V73101 Cbl-b-IN-8 2815223-33-5 Cbl-b-IN-8 (Compound 293) is an inhibitor (blocker/antagonist) of casitas b lineage lymphoma (Cbl-b) and c-Cbl? with IC50 of 5.5 nM and 7.8 nM respectively.
Cbl-b-IN-9 V73113 Cbl-b-IN-9 2815223-41-5 Cbl-b-IN-9 (Compound 300) is an inhibitor (blocker/antagonist) of casitas b-lineage lymphoma (Cbl-b) and c-Cbl with IC50 of 5.6 nM and 4.7 nM respectively.
CP2-CPP V132131 CP2-CPP CP2-CPP is a conjugate of the p27 analog CP2 and the Antennapedia peptide.
DCN1-UBC12-IN-2 V73112 DCN1-UBC12-IN-2 2374827-47-9 DCN1-UBC12-IN-2 is a potent and specific inhibitor of DCN1-UBC12 (IC50= 9.55 nM).
DCN1-UBC12-IN-4 V107005 DCN1-UBC12-IN-4 26028-65-9 DCN1-UBC12-IN-4 (compound 5p) is an inhibitor of DCN1-UBC12 with IC50＞10000 nM and exhibits antitumor activity.
DI-1548 V117317 DI-1548 2247060-97-3 DI-1548 is a potent, selective, and irreversible covalent inhibitor of DCN1 (IC50 = 4.6 nM).
DI-404 V73106 DI-404 2187412-79-7 DI-404 is a potent inhibitor of DCN1 with a Kd of 6.7 nM.
DI-591 V73086 DI-591 2245887-38-9 DI-591 is a potent, high-affinity and cell-permeable (penetrable) inhibitor of DCN1-UBC12 interaction.
EN219 V73105 1-3,5-bis(4-bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl-2-chloroethan-1-one 380351-29-1 EN219 is a synthetic covalent ligand with moderate specificity for the N-terminal cysteine C8 of RNF114, with IC50 of 470 nM.
FITC-Acp-RpYTPEP-NH2 V109047 FITC-Acp-RpYTPEP-NH2 FITC-Acp-RpYTPEP-NH2 is a potent fluorescent tracer.
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