A protein modifier called ubiquitin (UB) controls a variety of vital cellular functions. The E1 enzyme activates UB's C-terminal carboxylate to start the process of UB's transfer through the E1-E2-E3 cascade onto target proteins. The ubiquitin is attached to the E1 enzyme by a thioester bond during an ATP-dependent reaction, and this enzyme serves as the activating enzyme. The ubiquitin is transferred from the E1 enzyme to the conjugating E2 enzyme. The E3 enzyme, also known as the ubiquitin ligase, catalyzes the transfer of ubiquitin to the target protein (also known as the substrate) by forming an isopeptide bond.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73104 | Cbl-b-IN-7 | 2815221-35-1 | Cbl-b-IN-7 (Compound 248) is an inhibitor (blocker/antagonist) of casitas b lineage lymphoma (Cbl-b) and c-Cbl? with IC50 of 6.7 nM and 5.2 nM respectively. |
|
V73101 | Cbl-b-IN-8 | 2815223-33-5 | Cbl-b-IN-8 (Compound 293) is an inhibitor (blocker/antagonist) of casitas b lineage lymphoma (Cbl-b) and c-Cbl? with IC50 of 5.5 nM and 7.8 nM respectively. |
|
V73113 | Cbl-b-IN-9 | 2815223-41-5 | Cbl-b-IN-9 (Compound 300) is an inhibitor (blocker/antagonist) of casitas b-lineage lymphoma (Cbl-b) and c-Cbl with IC50 of 5.6 nM and 4.7 nM respectively. |
|
V73112 | DCN1-UBC12-IN-2 | 2374827-47-9 | DCN1-UBC12-IN-2 is a potent and specific inhibitor of DCN1-UBC12 (IC50= 9.55 nM). |
|
V107005 | DCN1-UBC12-IN-4 | 26028-65-9 | DCN1-UBC12-IN-4 (compound 5p) is an inhibitor of DCN1-UBC12 with IC50＞10000 nM and exhibits antitumor activity. |
|
V73106 | DI-404 | 2187412-79-7 | DI-404 is a potent inhibitor of DCN1 with a Kd of 6.7 nM. |
|
V73086 | DI-591 | 2245887-38-9 | DI-591 is a potent, high-affinity and cell-permeable (penetrable) inhibitor of DCN1-UBC12 interaction. |
|
V73105 | 1-3,5-bis(4-bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl-2-chloroethan-1-one | 380351-29-1 | EN219 is a synthetic covalent ligand with moderate specificity for the N-terminal cysteine C8 of RNF114, with IC50 of 470 nM. |
|
V87384 | HA-9104 | 2412367-83-8 | HA-9104 is a potent and selective cullin-5 neddylation inhibitor that targets the V30 pocket of UBE2F. |
|
V73088 | HB007 | 2387821-46-5 | HB007 is a small ubiquitin-related modifier 1 (SUMO1) degrader. |
|
V88506 | Hdm2 E3 ligase inhibitor 1 | 414905-09-2 | Hdm2 E3 ligase inhibitor 1 (Compound 1) is a reversible inhibitor of Hdm2 (an E3 ubiquitin ligase)-mediated p53 protein ubiquitination with IC50 of 12.7 μM. |
|
V73097 | HECT E3-IN-1 | 1810058-52-6 | HECT E3-IN-1 (compound 3) is an inhibitor (blocker/antagonist) of HECT E3 ligase. |
|
V105050 | HGC652 | 3055558-98-7 | HGC652 is a molecular glue that targets the E3 ubiquitin ligase TRIM21, promotes the formation of a ternary complex between TRIM21 and NUP98, and induces the degradation of NUP155 and nuclear pore complex proteins, leading to cell death. |
|
V76922 | HOIPIN-8 | HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with IC50 of 11 nM. | |
|
V83672 | ML307 | ||
|
V87395 | MS147 | MS147 is a VHL-based PROTAC PRC1 degrader. | |
|
V87385 | MS181 | MS181 (compound 1) is a potent cereblon (CRBN)-recruiting and EED-binding polycomb repressive complex 1 (PRC1) PROTAC degrader. | |
|
V80899 | Navtemadlin-d7 (AMG 232-d7; KRT-232-d7) | Navtemadlin-d7 is the deuterated form of Navtemadlin. | |
|
V88515 | p53-MDM2-IN-4 | 350678-63-6 | p53-MDM2-IN-4 (Example 4) is an inhibitor of p53-MDM2/X protein interaction with a Ki value of 3.079 μM. |
|
V104787 | Panepophenanthrin | 409064-57-9 | Permethrin is a compound isolated from the mushroom strain Panus rudis Fr. IFO 8994. |
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