Drug metabolites are created when a drug is metabolized into a different form that still has therapeutic effects. Active metabolites can be produced by drug metabolism redox reactions like heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations. In some rare circumstances, conjugation reactions can also produce an active metabolite.
Structure | Cat No. | Product Name | CAS No. | Product Description |
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V103485 | (-)-Verrucarol | 2198-92-7 | (-)-verrucarol is a trichothecene sesquiterpenoid, which is a hydrolysis product of natural Verrucarin A. |
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V107256 | (2'S)-Nicotine 1-oxide | 2820-55-5 | (2'S)-Nicotine 1-oxide ((2S)-Nicotine 1-N-oxide) is an alkaloid N-oxide found in the leaves, stems and roots of tobacco (Nicotiana tabacum). |
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V106502 | (2-Amino-5-bromophenyl)(pyridin-2-yl)methanone | 1563-56-0 | (2-Amino-5-bromophenyl)(pyridin-2-yl)methanone is a precursor for the synthesis of benzodiazepines and a hydrolysis product of clonazepam. |
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V72225 | (2-Hydroxyethoxy)acetic acid (β-hydroxyethoxyacetic acid; HEAA) | 13382-47-3 | (2-Hydroxyethoxy)acetic acid (β-hydroxyethoxyacetic acid) is the major urinary metabolite of 1,4-Dioxane. |
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V72236 | (25R)-12α-Hydroxyspirost-4-en-3-one | 50888-50-1 | (25R)-12α-Hydroxyspirost-4-en-3-one is a minor metabolite generated by Nocardia globerula on Hecogenin. |
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V32701 | (2S,4S)-Sacubitril | 149709-63-7 | 2S,4S-Sacubitril is an impurity of Sacubitril (AHU 377; AHU377;AHU-377), which is a US FDA approved drug used in combination with valsartan (trade name Entrosto for the combo)for the treatment of heart failure. |
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V72169 | (3,4,5-Trimethoxyphenyl)acetic-2,2 Acid-d2 | 344299-45-2 | (3,4,5-Trimethoxyphenyl)acetic-2,2 Acid-d2 is the deuterium labelled form of 3,4,5-Trimethoxyphenylacetic acid. |
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V102935 | (3R)-Hydroxyquinidine | 60761-51-5 | (3R)-Hydroxyquinidine is the major metabolite of quinidine. |
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V105906 | (3R,5R)-Octahydrocurcumin | 408324-14-1 | (3R,5R)-Octahydrocurcumin (Compound 7) is a metabolite of curcumin by intestinal flora. |
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V102621 | (3S,17S)-FD-895 | 2598242-04-5 | (3S,17S)-FD-895 is an analog of FD-895. |
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V105907 | (3S,5S)-Octahydrocurcumin | 112494-41-4 | (3S,5S)-Octahydrocurcumin ((3S,5S)-hexahydrobisdemethoxycurcumin) is a fungal metabolite that can be isolated from turmeric. |
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V72147 | (E)-10-Hydroxynortriptyline (E-10-OH-NT) | 47132-16-1 | (E)-10-Hydroxynortriptyline (E-10-OH-NT) is the metabolite of Nortriptyline. |
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V104772 | (E/Z)-Etherolenic acid | 2247927-22-4 | (E/Z)-Ethylene oleic acid is a divinyl ether oxidized lipid and a metabolite of linolenic acid. |
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V72206 | (R)-(-)-O-Desmethyl Venlafaxine-d6 ((R)-O-Desmethyl Venlafaxine-d6) | 1062609-96-4 | (R)-(-)-O-Desmethyl Venlafaxine-d6 is the deuterated form of (R)-(-)-O-Desmethyl Venlafaxine. |
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V105889 | (R)-Amino-N-benzyl-3-methoxypropionamide | 196601-69-1 | (R)-Amino-N-benzyl-3-methoxypropionamide is a stable intermediate of the antiepileptic drug lacosamide. |
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V72217 | (R)-tert-OMe-byakangelicin | 89560-97-4 | (R)-tert-OMe-byakangelicin is a furanocoumarin with inhibitory activity on hepatic drug metabolizing enzyme (DME) activity. |
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V102628 | (R)-γ-Valerolactone | 58917-25-2 | (R)-γ-Valerolactone is a precursor of antihypertensive compounds. |
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V101183 | (R,S,S)-Dihydrotetrabenazine | 924854-62-6 | (R,S,S)-Dihydrotetrabenazine (R,S,S-DHTBZ), a discrete isomeric secondary alcohol metabolite of tetrabenazine (TBZ), is a weak inhibitor of VMAT2 (Ki = 690 nM). |
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V72293 | (Rac)-Mono(3,5,5-trimethylhexyl) phthalate | 297182-83-3 | (Rac)-Mono(3,5,5-trimethylhexyl) phthalate is an important metabolite of widely used phthalate plasticizers. |
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V72258 | (rac)-N,O-Didesmethyl Tramadol-d3 | 1261398-22-4 | (rac)-N,O-Didesmethyl Tramadol-d3 is deuterium labeled (rac)-N,O-Didesmethyl Tramadol. |