Drug Metabolite

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Drug Metabolite

Drug metabolites are created when a drug is metabolized into a different form that still has therapeutic effects. Active metabolites can be produced by drug metabolism redox reactions like heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations. In some rare circumstances, conjugation reactions can also produce an active metabolite.

Drug Metabolite related products

Cat No.	Product Name	CAS No.	Product Description
V107414	α-Hydroxy etizolam	64546-10-7	α-Hydroxyetizolam is the major metabolite of etizolam and has almost the same pharmacological potency as etizolam and has a high affinity for benzodiazepine receptors.
V107680	α-Hydroxy flualprazolam	37115-46-1	Alpha-hydroxyfluanilide is a benzodiazepine.
V102990	α-Hydroxy Montelukast	2045402-27-3	α-Hydroxymontelukast (M7) is a metabolite of montelukast.
V72246	β-Nicotyrine	487-19-4	β-Nicotyrine is a metabolite of Nicotine.
V102982	Δ2-cis-Hexadecenoic acid	2825-68-5	Δ2-cis-hexadecenoic acid is an unsaturated fatty acid and a hydrolysis product of lipopolysaccharide.
V104573	Δ9-THCQ	860480-30-4	Δ9-THCQ (Δ9-tetrahydrocannabinol) is an oxidation byproduct of Δ9-THC.
V72143	ω-Hydroxy-DEET	72236-22-7	ω-Hydroxy-DEET is a major metabolite of the insect repellent DEET.
V40039	4-Desmethyl Istradefylline	160434-48-0	4-Desmethyl Istradefylline is the demethylated metabolite of Istradefylline （KW-6002; Nourianz), which is an orally bioavailable adenosine A2A receptor (A2AR) antagonist approved for the treatment of PD (Parkinson's disease).
V40057	Ezetimibe phenoxy glucuronide	190448-57-8	Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the bioactive metabolite of Ezetimibe and has anti-hyperlipoproteinemia effects.
V19605	Des(benzylpyridyl) Atazanavir	1192224-24-0	Des(benzylpyridyl) Atazanavir (compound M1) is an N-dealkylated Atazanavir metabolite.
V21871	Molsidomine	25717-80-0	Molsidomine is anorally bioactive and long acting vasodilator acting as anNO donor and annexin A2 inhibitor.
V16457	Oseltamivir carboxylate (GS 4071; Ro 64 0802)	187227-45-8	Oseltamivir acid (GS 4071), the bioactive metabolite of Oseltamivir phosphate, is an orally bioavailable and selective inhibitor of influenza virus neuraminidase (IC50=2 nM), active against both influenza viruses A and B.
V30699	Acetaminophen metabolite 3-hydroxy-acetaminophen	37519-14-5	3-hydroxy-acetaminophen is a metabolite of Acetaminophen.
V32638	Berberrubine chloride	15401-69-1	Berberrubine chloride, a potent metabolite of berberine, reduces symptoms of ulcerative colitis in animal models.
V3789	Niraparib metabolite M1	1476777-06-6	Niraparib metabolite M1 is a carboxylic acid metabolite of niraparib (MK4827; Zejula), which is a PARP1/2 inhibitor approved for cancer treatment.
V40035	m-Nifedipine	21881-77-6	m-Nifedipine is an impurity of Nifedipine (Bay-1040; BAY-a-1040; Cordipin; Corinfar) which is an approved dihydropyridine calcium channel blocker (CCB) used as antihypertensive drug.
V27881	Urolithin A	1143-70-0	Urolithin A isa microbial metabolite of ellagic acidin the gut and an inducer of mitophagy.
V40044	Dihydro Dutasteride	164656-22-8	Dihydro Dutasteride is an impurity generated during the production of Dutasteride (GI198745, GG745; GI-198745, GG-745;Avodart, Avidart), which is an approved anticancer medication and a 5-α reductase inhibitor.
V28672	Duloxetine metabolite Para-Naphthol Duloxetine	949095-98-1	Duloxetine metabolite Para-Naphthol Duloxetine is a metabolite of Duloxetine, which is a serotonin-norepinephrine reuptake inhibitor (SNRI)used for the treatment of major depressive disorder and generalized anxietydisorder (GAD),fibromyalgia and neuropathic pain.
V40125	Enzalutamide carboxylic acid	1242137-15-0	Enzalutamide carboxylic acid(also called MDV-3100 carboxylic acid)is a major inactive metabolite of Enzalutamide (MDV3100; Xtandi) which is a non-steroidal androgen-receptor (AR) antagonist approved for use as an anticancer drug.