Dipeptidyl Peptidases are widely distributed exopeptidases that possess central role in proteolysis.The DPP-IV family of dipeptidyl peptidases, which also includes DPP-7, DPP-8, DPP-9, fibroblast activation protein, and others, cleaves the peptide bond after the penultimate proline residue and has a large number of drug targets.
A serine protease known as DPP-IV (DPP4 or CD26) has been found on a number of immune cells and epithelial cells from different organs. A catalytically active soluble form of the enzyme is also found in several bodily fluids in addition to the membrane-bound enzyme. The N-termini of numerous chemokines, neuropeptides, and hormones are cleaved off by both variants, releasing dipeptides. By focusing on various substrates, DPP IV is essential for the regulation of the immune system, inflammation, oxidative stress, cell adhesion, and apoptosis. Drugs that inhibit DPP IV are frequently used to lower blood sugar.
DPP8 and DPP9 exhibit DPPIV-like activity and have a high degree of sequence similarity. Intracellular N-terminal dipeptidyl peptidases DPP8 and DPP9 (preferentially postproline) have been linked to pathophysiological roles in cancer biology and immune response.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V8225 | Teneligliptin (MP-513) | 760937-92-6 | Teneligliptin (MP513; trade name Tenelia in Japan) is a novel, potent, orally bioavailable and long-lasting dipeptidyl peptidase-4 (DPP-4) inhibitor; it competitively inhibited human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50 values of approximately 1 nM. |
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V32582 | Teneligliptin hydrobromide hydrate | 1572583-29-9 | Teneligliptin HBr hydrate (formerly MP513; MP-513; trade name Tenelia in Japan), the hydrobromide salt and hydrated form ofTeneligliptin, is an orally bioavailable and long-lasting dipeptidyl peptidase-4 (DPP-4) inhibitor approved for the treatment of type 2 diabetes mellitus in Japan. |
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V4579 | UAMC-00039 dihydrochloride | 697797-51-6 | UAMC00039 dihydrochloride is a novel, potent, reversible and competitivedipeptidyl peptidase II(DPP-II) inhibitor with anIC50of 0.48 nM. |
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V73068 | γ-Glu-Tyr | 7432-23-7 | γ-Glu-Tyr is a competitive inhibitor (IC50=6.77 mM) of dipeptidyl peptidase-IV (DPP-IV) and a potential functional ingredient in type 2 diabetes diets. |
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