Ceramidases are a group of enzymes that catalyze the hydrolysis of ceramide, dihydroceramide, and phytoceramide into sphingosine (SPH), dihydrosphingosine (DHS), and phytosphingosine (PHS), respectively, along with a free fatty acid.Ceramidases, which play a crucial role in the pathophysiology of diseases with altered lipid homeostasis like Alzheimer's disease, type 2 diabetes-induced insulin resistance, cancer, and cardiovascular conditions, regulate the breakdown of ceramides. According to the pH ideal for their catalytic activity, ceramidases are divided into the acid, neutral, and alkaline ceramidase subtypes.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73028 | (S,S)-Z-FA-FMK | 105637-38-5 | (S,S)-Z-FA-FMK is a cell-permeable (penetrable), irreversible inhibitor of cathepsin B. |
|
V73063 | 6,6′-Dihydroxythiobinupharidine | 30343-70-5 | 6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. |
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V73051 | ABP 25 | 2965359-45-7 | ABP 25 is an activity-based probe for imaging cathepsin K with good potency and selectivity. |
|
V73052 | Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 | 400716-78-1 | Ac-Glu-Asp(EDANS)-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Gly-Lys(DABCYL)-Glu-NH2 is a cathepsin D substrate for cathepsin D FRET Determination. |
|
V73062 | Ac-Leu-Val-Lys-Aldehyde | 147600-40-6 | Ac-Leu-Val-Lys-Aldehyde is a potent inhibitor of cathepsin B with IC50 of 4 nM. |
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V73060 | Ac-VLPE-FMK (Ac-Val-Leu-Pro-Glu(OMe)-CH2F) | 2679825-27-3 | Ac-VLPE-FMK is a tetrapeptide monofluoromethyl ketone (m-FMK), a Cat-B and Cat-L inhibitor. |
|
V73923 | Acid Ceramidase-IN-1 | 2415225-30-6 | Acid Ceramidase-IN-1 is a potent orally bioavailable acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM). |
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V73924 | Acid Ceramidase-IN-2 | 1005497-03-9 | Acid Ceramidase-IN-2 (compound 1) is an acid ceramidase (ceramidase) inhibitor (antagonist) with potential antiproliferation and cytostatic activity. |
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V119310 | Acid Ceramidase-IN-3 | 2907705-12-6 | Acid ceramidinase-IN-3 is an inhibitor of acid ceramidinase (aCDase). |
|
V128613 | ALT-007 | 2035010-37-6 | ALT-007 is an orally effective serine palmitoyltransferase (SPT) inhibitor that selectively reduces the levels of toxic, very long-chain deoxysphingolipids, thereby enhancing protein homeostasis. |
|
V110351 | AM9053 | 157469-21-1 | AM9053 is a highly selective, potent, slow-acting, and reversible inhibitor of N-acylethanolamine amidase (NAAA) (IC50 = 30 nM). |
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V73064 | Arg-Arg-AMC | 263843-55-6 | Arg-Arg-AMC is a selective substrate for Cathepsin B. |
|
V3381 | ARN14974 | 1644158-57-5 | ARN14974 (ARN-14974), a benzoxazolone carboxamide analog, is a novel and potent inhibitor of acid ceramidase with IC50of 79 nM. |
|
V73047 | ASPER-29 | 2630388-03-1 | ASPER-29 is an analog of Asperphenamate. |
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V73032 | Aurantiamide acetate (Asperglaucide) | 56121-42-7 | Aurantiamide acetate is a selective and orally bioactive cathepsin inhibitor extracted from Portulaca oleracea L. |
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V130839 | C16 Ceramide (d18:1(14Z)/16:0) | C16 Ceramide (d18:1(14Z)/16:0) is a sphingosine ceramide composed of long-chain sphingosine (d18:1) and palmitic acid (C16:0). | |
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V130882 | C22:1 1-Deoxyceramide (m18:1/22:1) | C22:1 1-Deoxyceramide (m18:1/22:1) is a deoxyceramide lipid lacking 1-hydroxyl groups and belongs to the ceramide variant. | |
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V73058 | Calpain-1 (pig) (μ-Calpain) | 689772-75-6 | Calpain-1 (pig) (μ-Calpain) is an intracellular Ca2+-regulated cysteine protease. |
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V73055 | Cathepsin C-IN-3 | 2825567-71-1 | Cathepsin C-IN-3 (compound SF11) is a potent inhibitor of cathepsin C (Cat C) with IC50 of 61.79 nM. |
|
V73056 | Cathepsin C-IN-4 | 2825567-86-8 | Cathepsin C-IN-4 (compound SF27) is a potent inhibitor of cathepsin C (Cat C) with IC50 of 65.6 nM. |
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