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    ARN14974
    ARN14974

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V3381
    CAS #: 1644158-57-5 Purity ≥98%

    Description: ARN14974 (ARN-14974), a benzoxazolone carboxamide analog, is a novel and potent inhibitor of acid ceramidase with IC50 of 79 nM. It inhibits acid ceramidase activity, reduces levels of sphingosine and dihydroceramide, and increases levels of ceramide in SW403 adenocarcinoma cells and RAW 264.7 murine macrophages when used at concentrations ranging from 0.1 to 20 mM. In vivo, ARN14974 (10 mg/kg, i.v.) reduces acid ceramidase activity in multiple organs, including brain, liver, heart, lungs, and kidney, and increases pulmonary ceramide levels in mice.

    References: Angewandte Chemistry International Edition English 54(2), 485-489 (2014).

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    ARN14974

    Name: ARN14974
    CAS#: 1644158-57-5
    Chemical Formula: C24H21FN2O3
    Exact Mass: 404.1536
    Molecular Weight: 404.4414
    Elemental Analysis: C, 71.27; H, 5.23; F, 4.70; N, 6.93; O, 11.87
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: ARN-14974; ARN14974; ARN 14974; Acid Ceramidase Inhibitor 17a;
    Chemical Name: 6-(4-fluorophenyl)-2-oxo-N-(4-phenylbutyl)-3(2H)-benzoxazolecarboxamide
    InChi Key: DPYVAZSLMQCVOG-UHFFFAOYSA-N
    InChi Code: InChI=1S/C24H21FN2O3/c25-20-12-9-18(10-13-20)19-11-14-21-22(16-19)30-24(29)27(21)23(28)26-15-5-4-8-17-6-2-1-3-7-17/h1-3,6-7,9-14,16H,4-5,8,15H2,(H,26,28)
    SMILES Code: O=C(N1C(OC2=CC(C3=CC=C(F)C=C3)=CC=C12)=O)NCCCCC4=CC=CC=C4


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    ARN14974 (ARN-14974), a benzoxazolone carboxamide analog, is a novel and potent inhibitor of acid ceramidase with IC50 of 79 nM. It inhibits acid ceramidase activity, reduces levels of sphingosine and dihydroceramide, and increases levels of ceramide in SW403 adenocarcinoma cells and RAW 264.7 murine macrophages when used at concentrations ranging from 0.1 to 20 mM. In vivo, ARN14974 (10 mg/kg, i.v.) reduces acid ceramidase activity in multiple organs, including brain, liver, heart, lungs, and kidney, and increases pulmonary ceramide levels in mice.

    References: Angewandte Chemistry International Edition English 54(2), 485-489 (2014).


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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