Aldose reductase is a tiny, cytosolic, monomeric enzyme that is a member of the aldo-keto reductase superfamily. Numerous aromatic and aliphatic carbonyl compounds are reduced by aldose reductase using the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH). It has been linked to the emergence of diabetic and galactosemic complications that affect the kidney, nerves, lens, and retina.
Aldose reductase is a crucial polyol pathway enzyme that, when activated under hyperglycemic conditions, causes the development of chronic diabetic complications. It is also a key factor in the promotion of inflammatory and cytotoxic conditions, even when blood sugar levels are normal. Aldose reductase is a fantastic drug target, and there is a lot of work being done to identify new substances that can inhibit it.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V87280 | Floramanoside D | 1487423-55-1 | Floramanoside D is a flavonol glycoside. |
|
V73730 | Ganoderic acid C6 | 105742-76-5 | Ganoderic acid C6 has aldose reductase inhibitory activity. |
|
V73735 | Ganoderic acid Df | 1352033-73-8 | Ganoderic acid Df is a lanosterane-type triterpenoid compound that can be extracted from the fruiting bodies of Ganoderma lucidum. |
|
V99107 | LX1 | 2647877-84-5 | LX1 is an anti-prostate cancer compound that targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. |
|
V105959 | Mumeose K | 2132384-01-9 | Mumeose K is an aldose reductase inhibitor with IC50 of 27 μM. |
|
V73738 | Myrciacetin | 203734-35-4 | Myrciacetin is a flavonoid. |
|
V103439 | WF-3681 | 105364-56-5 | WF-3681 (Compound 1) is an aldose reductase inhibitor and fungal metabolite. |
|
V73736 | β-Glucogallin (1-O-Galloyl-β-D-glucose) | 13405-60-2 | β-Glucogallin is a potent and specific aldose reductase (AKR1B1) inhibitor. |
|
V24126 | Lidorestat | 245116-90-9 | Lidorestat (EML-676;ALN-101; IDD-000676-01;IDD-676) is a novel and potent aldose reductase inhibitor which isorally bioactive and can be used to treat chronic diabetes complications. |
|
V28535 | Zopolrestat | 110703-94-1 | Zopolrestat (CP-73850; CP73850) is a novel and potent aldose reductase inhibitor (IC50 = 3.1 nM) with the potentialfor the treatment of diabetic nephropathy and diabetes. |
|
V2013 | Isoliquiritigenin (GU17) | 961-29-5 | Isoliquiritigenin (also known as ISL; GU17; Isoliquiritigen) is a naturally occuring chalcone compound and NLRP3 antagonist found in licorice root and several other plants that displays antioxidant, anti-inflammatory, and antitumor activities as well as hepatoprotection against steatosis-induced oxidative stress. |
|
V14560 | Tolrestat (AY-27773) | 82964-04-3 | Tolrestat is a potent, orally bioavailable aldose reductase inhibitor (antagonist) with IC50 of 35 nM. |
|
V5317 | Ponalrestat | 72702-95-5 | Ponalrestat (MK-538; ICI 128436; Statil) is a novel and potent aldose reductase inhibitor which inhibits the conversion of glucose to sorbitol. |
|
V28701 | Poliumoside | 94079-81-9 | Poliumoside possesses significant antiinflammatory and antioxidant activity, It is a novel and potent natural compound and isisolated fromBrandisia hanceistems and leaves. |
|
V12303 | Ranirestat | 147254-64-6 | Ranirestat (AS-3201; SX-3201) is a novel, oral and potent aldose reductase inhibitorwith the potential for the treatment of diabetic neuropathy. |
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