By making blood vessels tighten, the angiotensin-converting enzyme (ACE) indirectly raises blood pressure. Angiotensin I is changed by ACE into angiotensin II, which tightens the blood vessels. The renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body, is made up of ACE, angiotensin I, and angiotensin II. Cells in the endothelium (inner layer) of blood vessels secrete ACE in the lungs and kidneys. It serves two main purposes: In a substrate concentration-dependent manner, ACE catalyzes the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor.Bradykinin, a potent vasodilator, and other vasoactive peptides are broken down by ACE. In order to treat conditions like high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus, ACE inhibition is a goal. Angiotensin II production and bradykinin metabolism are both reduced when ACE is inhibited (by ACE inhibitors), which results in a general dilation of the arteries and veins and a reduction in arterial blood pressure.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73010 | Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine | 198284-23-0 | Lactalbumin B (50-53) Alpha [Lactorphin Alpha], bovine is a 4-amino acid (AA) antihypertensive peptide. |
|
V73000 | Lyciumin A | 125708-06-7 | Lyciumin A is a cyclic octapeptide with inhibitory effect against proteases, renin, and angiotensin-converting enzyme. |
|
V72994 | Mca-Ala-Pro-Lys(Dnp)-OH | 305336-82-7 | Mca-Ala-Pro-Lys(Dnp)-OH is a specific ACE2 quenching fluorescent substrate that may be utilized to detect urinary, heart and lung ACE2 activity. |
|
V26879 | Olumacostat glasaretil | 1261491-89-7 | Olumacostat glasaretil (OG) is a novel and potent acetyl-CoA carboxylase inhibitor with anti-inflammatory effects. |
|
V2076 | Omapatrilat (BMS-186716) | 167305-00-2 | Omapatrilat (also known asVanlev;BMS-186716) is a novel investigational antihypertensive agent that acts as apotent dual inhibitor of the metalloproteasesACE (angiotensin converting enzyme)andNEP (neutral endopeptidase)withKivalues of 0.64 and 0.45 nM, respectively. |
|
V73002 | Ovalbumin (154-159) | 1370698-94-4 | Ovalbumin (154-159) is a fragment of ovalbumin. |
|
V73003 | Ovotransferrin (328-332) | 1226776-54-0 | Ovotransferrin (328-332) has a protective effect on blood pressure by inhibiting Angiotensin-Converting Enzyme (ACE), with IC50 of 20μM. |
|
V73007 | p-Hydroxyhippuryl-His-Leu | 77697-23-5 | p-Hydroxyhippuryl-His-Leu is a bioactive peptide substrate of ACE (angiotensin-converting enzyme). |
|
V73019 | Quinaprilat-d5 (quinapril-d5) | 1279034-23-9 | Quinaprilat-d5 is a deuterium labelled form of Quinaprilat. |
|
V13596 | Ramiprilat | 87269-97-4 | Ramiprilat, theactive metabolite ofRamipril (HOE-498), is a novel and potent angiotensin-converting enzyme (ACE) inhibitor used as anantihypertensive drug. |
|
V72999 | Spirapril hydrochloride (SCH 33844 hydrochloride) | 94841-17-5 | Spirapril (SCH 33844) HCl is a potent angiotensin-converting enzyme (ACE) inhibitor (antagonist) with antihypertensive effects. |
|
V16691 | Trandolapril (RU44570) | 87679-37-6 | Trandolapril(RU-44570; Mavik; Gopten;RU44570; Odrik), an antihypertensive drug, is anoral andnonsulfhydryl prodrug that has to be hydrolysed to the active diacid Trandolaprilat. |
|
V73018 | Trandolapril hydrochloride (RU44570 hydrochloride) | 87725-72-2 | Trandolapril (RU44570) HCl is a non-sulfhydryl precursor compound that hydrolyzes to active diacetyl (Trandolapril HClat). |
|
V73008 | Vasicinol (6-Hydroxypeganine) | 5081-51-6 | Vasicinol is a reversible inhibitor of sucrase (IC50= 250 μM). |
|
V19065 | Vicenin 2 | 23666-13-9 | Vicenin 2 is a flavonoid and an orally bioactive ACE (angiotensin-converting enzyme) inhibitor (IC50 of 43.83 μM). |
|
V72995 | Vicenin-1 (Vicenin-1) | 35927-38-9 | Vicenin 1 is a glycosyl flavonoid that can inhibit ACE (angiotensin-converting enzyme) (IC50=52.50 μM). |
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