A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.
TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V121961 | (R)-SARM1-IN-5 | 2762081-31-0 | (R)-SARM1-IN-5 is the (R)-enantiomer of SARM1-IN-5. |
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V118689 | (Rac)-VB-201 | 873842-97-8 | (Rac)-VB-201 is the racemic form of VB-201, a small oxidized phospholipid molecule that inhibits CD14 and Toll-like receptor 2-dependent innate cell activation and suppresses atherosclerosis. |
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V122269 | (S,S)-SARM1-IN-9 | 3020765-70-9 | (S,S)-SARM1-IN-9 is a stereoselective SARM1 inhibitor with covalent binding properties. |
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V40665 | 1V209 | 1062444-54-5 | 1V209 is a novel and potent Toll-like receptor 7 (TLR7) agonistwithanti-tumor activity. |
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V120030 | 3A-MPLA ammonium | 1699735-80-2 | 3A-MPLA ammonium, a triacyl monophosphate lipid A, is a TLR-4 agonist. |
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V125364 | 3D-Monophosphoryl Lipid (12,16) free acid | 220048-49-7 | 3D-Monophosphoryl Lipid (12,16) free acid is a TLR4 agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines. |
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V103643 | 3D-Monophosphoryl Lipid (12,16) triethylamine | 3D-monophosphoryl lipid (12,16) (triethylamine) is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines. | |
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V103642 | 3D-Monophosphoryl Lipid (14) ammonium | 3D-monophosphoryl lipid (14) (ammonium) is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines. | |
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V103641 | 3D-Monophosphoryl Lipid (14) triethylamine | 252042-60-7 | 3D-monophosphoryl lipid (14) triethylamine is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines. |
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V107775 | 3D-Monophosphoryl Lipid A-5 free acid | 1465797-24-3 | 3D-monophosphoryl lipid A-5 (free acid) is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines. |
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V107776 | 3D-Monophosphoryl Lipid A-5 triethylamine | 3D-monophosphoryl lipid A-5 (3D-MPLA-5) triethylamine is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines. | |
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V106930 | 4-Octylphenol | 1806-26-4 | 4-Octylphenol is a hormone disruptor with sex-specific effects on male germ cells, significantly reducing the mitotic index and the number of prespermatogonia. |
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V74350 | 6'-Sialyllactose | 35890-39-2 | 6'-Sialyllactose is a sialylated human milk oligosaccharide that promotes the proliferation of bifidobacteria and shapes the intestinal microbiota. |
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V128024 | ABB071 | ABB071 is a humanized anti-CD180 monoclonal antibody. | |
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V128032 | ABC-015 | ABC-015 is a human monoclonal antibody (mAb) that targets KLRG1. | |
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V74342 | ABR-238901 | 1638200-22-2 | ABR-238901 is an orally bioactive S100A8/A9 blocker that can inhibit the interaction of S100A8/A9 with its receptors RAGE (receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). |
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V74343 | Afimetoran (BMS-986256) | 2171019-55-7 | Afimetoran is a toll-like receptor blocker (antagonist) that may be utilized in the research/study of inflammatory and autoimmune diseases. |
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V74373 | Agatolimod sodium (ODN 7909; PF-3512676; CpG 7909) | 541547-35-7 | Agatolimod sodium (ODN 7909) is a class B CpG ODN and a< B >TLR9 agonist. |
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V128631 | Aluminum hydroxide adjuvant aluminum : 4~6 mg/mL | Aluminum hydroxide adjuvant aluminum: 4~6 mg/mL is a micron-sized water-based aluminum hydroxide adjuvant with an aluminum content of 4~6 mg/mL. | |
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V129069 | Anti-inflammatory agent 97 | Anti-inflammatory agent 97 is an anti-inflammatory agent that also inhibits oxidative stress. |
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