A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.
TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V118689 | (Rac)-VB-201 | 873842-97-8 | (Rac)-VB-201 is the racemic form of VB-201, a small oxidized phospholipid molecule that inhibits CD14 and Toll-like receptor 2-dependent innate cell activation and suppresses atherosclerosis. |
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V40665 | 1V209 | 1062444-54-5 | 1V209 is a novel and potent Toll-like receptor 7 (TLR7) agonistwithanti-tumor activity. |
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V120030 | 3A-MPLA ammonium | 1699735-80-2 | 3A-MPLA ammonium, a triacyl monophosphate lipid A, is a TLR-4 agonist. |
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V103643 | 3D-Monophosphoryl Lipid (12,16) triethylamine | 3D-monophosphoryl lipid (12,16) (triethylamine) is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines. | |
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V103642 | 3D-Monophosphoryl Lipid (14) ammonium | 3D-monophosphoryl lipid (14) (ammonium) is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines. | |
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V103641 | 3D-Monophosphoryl Lipid (14) triethylamine | 252042-60-7 | 3D-monophosphoryl lipid (14) triethylamine is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines. |
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V107775 | 3D-Monophosphoryl Lipid A-5 free acid | 1465797-24-3 | 3D-monophosphoryl lipid A-5 (free acid) is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines. |
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V107776 | 3D-Monophosphoryl Lipid A-5 triethylamine | 3D-monophosphoryl lipid A-5 (3D-MPLA-5) triethylamine is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines. | |
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V106930 | 4-Octylphenol | 1806-26-4 | 4-Octylphenol is a hormone disruptor with sex-specific effects on male germ cells, significantly reducing the mitotic index and the number of prespermatogonia. |
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V74350 | 6'-Sialyllactose | 35890-39-2 | 6'-Sialyllactose is a sialylated human milk oligosaccharide that promotes the proliferation of bifidobacteria and shapes the intestinal microbiota. |
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V74342 | ABR-238901 | 1638200-22-2 | ABR-238901 is an orally bioactive S100A8/A9 blocker that can inhibit the interaction of S100A8/A9 with its receptors RAGE (receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). |
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V74343 | Afimetoran (BMS-986256) | 2171019-55-7 | Afimetoran is a toll-like receptor blocker (antagonist) that may be utilized in the research/study of inflammatory and autoimmune diseases. |
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V74373 | Agatolimod sodium (ODN 7909; PF-3512676; CpG 7909) | 541547-35-7 | Agatolimod sodium (ODN 7909) is a class B CpG ODN and a< B >TLR9 agonist. |
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V115689 | APG-7 | APG-7 binds to the TLR4/MD-2 interface, thereby inhibiting NO production (IC50: 24.2 μg/mL). | |
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V51784 | AXC-715 hydrochloride | 2490497-93-1 | AXC-715 (T785) HCl is a TLR7/TLR8 dual agonist obtained from patent WO2020168017 A1. |
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V103687 | AYK004 | 3031612-90-2 | AYK004 is a TLR7/8 agonist that can enhance immune responses by activating the TLR signaling pathway. |
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V103685 | AYK004-B1 | 3031612-91-3 | AYK004-B1 is a TLR7 agonist (EC50=0.2265 nM). |
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V103684 | AYK004-C1 | 3031612-92-4 | AYK004-C1 is a TLR agonist that can be used to prepare immune adjuvants. |
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V103689 | AYK005 | 3031612-93-5 | AYK005 is a TLR7/8 type vaccine adjuvant. |
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V116846 | Bazlitoran | 1378549-07-5 | Bazlitoran is an oligonucleotide that can act as an antagonist for TLR7, TLR8 and TLR9. |
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