| Size | Price | Stock | Qty |
|---|---|---|---|
| 1mg |
|
||
| 5mg |
|
||
| 10mg | |||
| Other Sizes |
| References |
|
|---|---|
| Additional Infomation |
Afinmetolan is an immunomodulator and an antagonist of TLR 7 and 8. It is currently being investigated in the clinical trial NCT04269356 (a study evaluating the absorption, distribution, breakdown, and elimination of radioactive BMS-986256 in humans).
Mechanism of Action Afinmetolan acts as an antagonist of TLR 7/8. |
| Molecular Formula |
C26H32N6O
|
|---|---|
| Molecular Weight |
444.571885108948
|
| Exact Mass |
444.263
|
| CAS # |
2171019-55-7
|
| PubChem CID |
132271862
|
| Appearance |
White to off-white solid powder
|
| LogP |
3.9
|
| Hydrogen Bond Donor Count |
2
|
| Hydrogen Bond Acceptor Count |
4
|
| Rotatable Bond Count |
5
|
| Heavy Atom Count |
33
|
| Complexity |
694
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
O=C(CN1CCC(C2C=CC3=C(C(C(C)C)=C(C4=CN5C(C(C)=C4C)=NC=N5)N3)C=2)CC1)N
|
| InChi Key |
SNFVHLQYHFQOEP-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C26H32N6O/c1-15(2)24-20-11-19(18-7-9-31(10-8-18)13-23(27)33)5-6-22(20)30-25(24)21-12-32-26(28-14-29-32)17(4)16(21)3/h5-6,11-12,14-15,18,30H,7-10,13H2,1-4H3,(H2,27,33)
|
| Chemical Name |
2-[4-[2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-propan-2-yl-1H-indol-5-yl]piperidin-1-yl]acetamide
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: 100 mg/mL (224.94 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.62 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.62 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (5.62 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2494 mL | 11.2468 mL | 22.4936 mL | |
| 5 mM | 0.4499 mL | 2.2494 mL | 4.4987 mL | |
| 10 mM | 0.2249 mL | 1.1247 mL | 2.2494 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Link: https://clinicaltrials.gov/ct2/show/NCT04895696
Conditions:Systemic Lupus ErythematosusLink: https://clinicaltrials.gov/ct2/show/NCT04470778
Conditions:Healthy ParticipantsLink: https://clinicaltrials.gov/ct2/show/NCT05866627
Conditions:Healthy Volunteers
Title:A Study to Assess the Effect of Phenytoin on the Drug Levels of Afimetoran and the Effect of Afimetoran on the Drug Levels of Midazolam
Status:Completed
updateDate:2024-08-07
Ctid:NCT05901714
Link: https://clinicaltrials.gov/ct2/show/NCT05901714
Conditions:Healthy ParticipantsLink: https://clinicaltrials.gov/ct2/show/NCT04493541
Conditions:Lupus Erythematosus, CutaneousLink: https://clinicaltrials.gov/ct2/show/NCT04016753
Conditions:Healthy ParticipantsLink: https://clinicaltrials.gov/ct2/show/NCT04941755
Conditions:Healthy ParticipantsLink: https://clinicaltrials.gov/ct2/show/NCT04269356
Conditions:Healthy ParticipantsLink: https://clinicaltrials.gov/ct2/show/NCT04039373
Conditions:Healthy ParticipantsLink: https://clinicaltrials.gov/ct2/show/NCT03634995
Conditions:Healthy ParticipantsLink: https://clinicaltrials.gov/ct2/show/NCT03950960
Conditions:Healthy ParticipantsProducts are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
