Reactive oxygen species (ROS) are radical and non-radical oxygen species produced by the partial reduction of oxygen, including superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•). Endogenous ROS are produced by cells during their normal oxidative metabolism in the mitochondria as well as when they react to xenobiotics, cytokines, and bacterial invasion.
By directly inhibiting MAPK phosphatases, ROS also activates MAPK pathways. Through PTEN, ROS produced by growth factor stimulation are capable of reversibly controlling the redox state of the PI3K pathway. The cellular response to ROS may involve the activation of autophagy.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V104556 | TBC-1 | 2522115-48-4 | TBC-1, a chlorophyll-a derivative, is a photosensitizer used in photodynamic therapy (PDT). |
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V105299 | TFGF-18 | 2222662-20-4 | TFGF-18 is a GSK-3β inhibitor (IC50: 0.59 μM). |
|
V90782 | Timosaponin E2 | 222018-47-5 | Timosaponin E2 is an anti-inflammatory agent and inhibits the production of reactive oxygen species. |
|
V103713 | Top/HDAC-IN-3 | 3059615-90-3 | Top/HDAC-IN-3 (compound 31) is an orally active dual inhibitor of topoisomerase and HDAC. |
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V72935 | Topo I-IN-1 | 2763655-68-9 | Topo I-IN-1 (Compound 14d) is a Topo I inhibitor (antagonist) with anti-tumor activity and DNA intercalation ability. |
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V72958 | Topo I/COX-2-IN-2 | 2841455-91-0 | Topo I/COX-2-IN-2 (Compound W10) is a potent dual-target inhibitor of Topo I and COX-2 with IC50s of 0.90 μM and 2.31 μM respectively. |
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V104482 | Topoisomerase I inhibitor 17 | 2413582-45-1 | Topoisomerase I inhibitor 17 (compound 7h) is a topoisomerase I (Top1) inhibitor. |
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V69217 | Topoisomerase I/II inhibitor 3 | 2770804-74-3 | Topoisomerase I/II inhibitor 3 (7) is a potent dual (bifunctional) inhibitor of topoisomerase I (Topo I) and II (Topo II). |
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V89042 | TPA-NAC | TPA-NAC is a non-fluorescent prodrug, which is prepared by introducing N-acetyl-L-cysteine (NAC) into the conjugated receptor backbone. | |
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V3251 | TPEN | 16858-02-9 | TPEN (also known as TPED) is a specific cell-permeable heavy metal chelator. |
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V107875 | Triphenyl phosphate | 115-86-6 | Triphenyl phosphate is an organophosphate flame retardant. |
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V105413 | TrxR-IN-7 | TrxR-IN-7 (14f) is a potent thioredoxin reductase (TrxR) inhibitor with IC50 of 3.5 µM. | |
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V72913 | Tubulin polymerization-IN-6 | 2768613-52-9 | Tubulin polymerization-IN-6 (compound 5f) is a potent inhibitor of tubulin polymerization with IC50 of 1.09 μM. |
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V71961 | Tyrosinase-IN-12 | 1860779-42-5 | noncompetitive tyrosinase inhibitor (Tyrosinase-IN-12) is a potent, noncompetitive antioxidant and tyrosinase inhibitor (antagonist) with IC50 of 49.33 ± 2.64 µM and a Ki of 31.25 ± 0.25 µM. |
|
V101128 | U-78517 | 122003-11-6 | U-78517 is a powerful antioxidant. |
|
V88581 | ULK1-IN-3 | ULK1-IN-3 (Compound 8) is a novel chromone-based potential ULK1 inhibitor. | |
|
V105161 | VEGFR-2-IN-61 | VEGFR-2-IN-61 (Compound 7b) is an inhibitor of VEGFR-2 with IC50 of 2.83 µM. | |
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V19746 | Visomitin (SKQ-1) | 934826-68-3 | Visomitin (SKQ1; plastoquinonyl decyltriphenyl phosphonium; PDTP) is a higly potent mitochondria-targeted antioxidant and topical cardiolipin peroxidation inhibitor with excellent mitochondrion membrane penetrating ability. |
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V72885 | Xanthine oxidase | 9002-17-9 | Xanthine oxidase is a xanthine oxidoreductase that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid. |
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V80151 | Xanthine oxidase-IN-12 | Xanthine oxidase-IN-12 (Compound 11) is a xanthine oxidase (XO) inhibitor (antagonist) with IC50 of 91 nM. |
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