Size | Price | Stock | Qty |
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1mg |
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5mg |
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10mg |
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Other Sizes |
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Targets |
Galectin-3
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ln Vitro |
G3-C12(TFA) is a peptide that binds to galectin-3 with a high affinity (Kd) of 88 nM; it has no affinity for other lectins or members of the galectin family. When compared to the galactose containing copolymer, G3-C12(TFA) bearing opolymers N-(2-hydroxypropyl)methacrylamide (HPMA) exhibits improved targetability to galectin-3 and can effectively and selectively target colorectal cancer (CRC) tumor cells that overexpress galectin-3[1].
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References |
[1]. Kopansky E, et al. Peptide-directed HPMA copolymer-doxorubicin conjugates as targeted therapeutics for colorectal cancer. J Drug Target. 2011 Dec;19(10):933-43.
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Molecular Formula |
C74H115N23O23S2.C2HF3O2
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Molecular Weight |
1873.00
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Related CAS # |
G3-C12;848301-94-0
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Solubility (In Vitro) |
H2O :≥ 50 mg/mL (~26.70 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: 12.5 mg/mL (6.67 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 0.5339 mL | 2.6695 mL | 5.3390 mL | |
5 mM | 0.1068 mL | 0.5339 mL | 1.0678 mL | |
10 mM | 0.0534 mL | 0.2670 mL | 0.5339 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.