The enzyme cyclooxygenase (COX), also referred to as prostaglandin-endoperoxide synthase (PTGS), is in charge of producing the vital biological mediators known as prostanoids, such as prostaglandins, prostacyclin, and thromboxane. Pain and inflammation symptoms can be reduced by pharmacologically inhibiting COX. The general public has had access to cyclooxygenase activity-inhibiting medications for about 100 years, including aspirin. The two cyclooxygenase isoforms, COX-1 and COX-2, have been identified. The COX-1 enzyme is frequently produced constitutively (i.e., in the gastric mucosa), whereas the COX-2 enzyme is induced (i.e., at sites of inflammation). Aspirin and ibuprofen are examples of NSAIDs that work by inhibiting COX to produce their desired effects. The non-steroidal anti-inflammatory drugs (NSAIDs) are the primary COX inhibitors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V31967 | Parecoxib (SC 69124) | 198470-84-7 | Parecoxib (SC69124A; Dynastat) is a selective cyclooxygenase-2 (COX-2) inhibitor with the potentialfor treating postoperative pain in adults. |
|
V13747 | Parecoxib sodium | 198470-85-8 | Parecoxib sodium (SC-69124A; Dynastat) is a novel and potent cyclooxygenase-2/COX-2 inhibitor with the potentialfor treating postoperative pain in adults. |
|
V2006 | Rutaecarpine (Rutecarpine) | 84-26-4 | Rutaecarpine (also known as rutecarpine; Rutacarpine; Rutaecarpin; Rhetine) is a naturally occuring indolopyridoquinazolinone alkaloid isolated from isolated from the chinese herb Evodia rutaecarpa which has vasorelaxing effect and inhibits platelet aggregation and Cox-2. |
|
V14565 | S-Diclofenac | 912758-00-0 | S-Diclofenac (ACS-15, ATB-337; ACS15, ATB337), ahybrid molecule of an H2S donor and the diclofenac, is a potent non-steroidal anti-inflammatory drug (NSAID). |
|
V3418 | SC-560 | 188817-13-2 | SC-560 is a novel, potent,orally bioavailable and selectiveCOX-1 (cyclooxygenase-1)inhibitor with anIC50of 9 nM. |
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V33149 | Syringaldehyde | 134-96-3 | Syringaldehyde is a flavonoid polyphenolic compound found in different plant species like Manihot esculenta and Magnolia officinalis. |
|
V16200 | TFAP | 1011244-68-0 | TFAP is a cell-permeable pyridinyl-benzamide compound that acts as a COX-1-selective inhibitor by targeting the enzymes active site. |
|
V16407 | Tiaprofenic acid | 33005-95-7 | Tiaprofenic acid (Surgam, Surgamyl and Tiaprofen) is a non-steroidal anti-inflammatory drug (NSAID) approvedfor the treatment of pain, especially arthritic pain. |
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