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    PF-06928215
    PF-06928215

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V4559
    CAS #: N/APurity ≥98%

    Description: PF-06928215 is a novel, potent, high affinity and selective cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 μΜ. PF-06928215 is a high affinity (KD = 200 nM) active site-targeting, substrate-competitive cyclic GMP-AMP synthase (cGAS) inhibitor (IC50 = 4.9 μM; in the presence of 1 mM ATP, 0.3 mM GTP, 100 nM 45-bp interferon-stimulatory dsDNA (ISD)). PF-06928215 displays no inhibitory potency against dsDNA-induced IFN-β expression in cellular cGAS assays, most likely due to limited cell-permeability and/or high levels of cellular ATP and GTP in the reporter cells employed.

    ReferencesPLoS One. 2017 Sep 21;12(9):e0184843.


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    PF-06928215

    Molecular Weight: 380.40
    Formula: C₂₀H₂₀N₄O₄
    SMILES: OC1=CC(C2=CC=CC=C2)=NC3=C(C(N[[email protected]]4CCCC[[email protected]]4C(O)=O)=O)C=NN13
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationPF-06928215; PF 06928215; PF06928215


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