A non-apoptotic type of controlled cell death is ferroptosis. It differs from other types of controlled cell death, like apoptosis and necroptosis. Large-scale lipid peroxidation, which is a hallmark of ferroptosis, can be prevented by lipophilic antioxidants or iron chelators. Ferroptosis inducers can be categorized into two groups based on their mechanisms: (1) inhibitors of cystine import via system xc (such as Erastin), which lead to the depletion of glutathione (GSH), and (2) covalent inhibitors of glutathione peroxidase 4 (GPX4), such as (1S, 3R)-RSL3.Both compound classes ultimately lead to a loss of GPX4 activity, which is followed by increased levels of lipid reactive oxygen species (ROS) and eventual cell death. GPX4 reduces lipid hydroperoxides using GSH as a co-substrate.
Iron and ROS are required for the regulated cell death (RCD) process known as ferroptosis. Misregulated ferroptosis has been linked to a number of physiological and pathological processes, such as T-cell immunity, drug-induced hepatotoxicity, hepatic and heart ischemia/reperfusion injury, neurotoxicity, and the death of cancer cells.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V34159 | NADPH tetracyclohexanamine | 100929-71-3 | NADPH tetracyclohexanamine (NADPH;β-NADPH; TPNH), thetetracyclohexanamine salt form of NADPH (β-Nicotinamide adenine dinucleotide phosphate),is a potent cofactor and biological reducing agent, alsoan electron donor and a cofactor for nitric oxide synthetase. |
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V80908 | NC-R17 | NC-R17 is an RSL3-based non-covalent GPX4 degrader that participates in ferroptosis. | |
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V51332 | Rosiglitazone-d3 (BRL-49653-d3) | 1132641-22-5 | deuterated form of Rosiglitazone |
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V2338 | SRS11-92 | 1467047-25-1 | SRS11-92 is a Ferrostatin-1 (Fer-1) analog and a potent inhibitor of ferroptosis. |
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V4269 | UAMC-3203 | 2271358-64-4 | UAMC-3203 (UAMC3203) is a novel and selectiveFerroptosisinhibitor with anIC50value of 12 nM. |
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V4440 | UAMC-3203 HCl | 2271358-65-5 | UAMC-3203HCl(UAMC3203 hydrochloride) is a novel, potent, and selectiveFerroptosisinhibitor (IC50value =12 nM) with higher solublility and anti-inflammatory/antioxidant effects. |
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V61783 | viFSP1 | 951945-67-8 | viFSP1 is a species-independent inhibitor of FSP1 that induces ferroptosis in FSP1-dependent cells. |
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V76347 | W1131 TFA | W1131 TFA is a potent STAT3 inhibitor that cancause ferroptosis. | |
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V73488 | YL-939 | YL-939 is a potent inhibitor of ferroptosis. |
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