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    UAMC-3203 HCl
    UAMC-3203 HCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4440
    CAS #: 2271358-65-5Purity ≥98%

    Description: UAMC-3203 HCl is a novel, potent, more soluble and selective Ferroptosis inhibitor with an IC50 value of 12 nM. Ferroptosis is an iron-catalyzed, nonapoptotic form of regulated necrosis that results in oxidative lipid damage in cell membranes that can be inhibited by the radical-trapping antioxidant Ferrostatin-1 (Fer-1). Novel inhibitors derived from the Fer-1 scaffold inhibited ferroptosis potently but suffered from solubility issues. No toxicity was observed in mice after daily injection of UAMC-3203 for 4 weeks. UAMC-3203 inserts rapidly in a phospholipid bilayer in silico, which aligns with the current understanding of the mechanism of action of these compounds. In conclusion, these analogues have superior properties compared to Fer-1, show in vivo efficacy, and represent novel lead compounds with therapeutic potential in relevant ferroptosis-driven disease models.

    References: J Med Chem. 2018 Nov 21;61(22):10126-10140.

    Related CAS: 2271358-64-4 (free base)

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    UAMC-3203 HCl

    Molecular Weight: 508.12
    Formula: C₂₅H₃₈ClN₅O₂S
    CAS No.: 2271358-65-5
    SMILES: O=S(C(C=C1NCC2=CC=CC=C2)=CC=C1NC3CCCCC3)(NCCN4CCNCC4)=O.Cl
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationUAMC-3203 HCl; UAMC 3203; UAMC3203; 


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