A family of proteins known as Bcl-2 have evolutionary connections. These proteins, which include Bcl-2 proper, Bcl-xL, and Bcl-w among a variety of others, control mitochondrial outer membrane permeabilization (MOMP). They can either be pro- or anti-apoptotic. The Bcl-2 family comprises a total of 25 known genes. These human genes include Bak1, Bax, Bal-2, Bok, and Mcl-1, which code for members of this family of proteins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V76048 | Mcl-1 inhibitor 17 | 892250-00-9 | Mcl-1 inhibitor 17 is a Mcl-1 protein inhibitor. |
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V83542 | Mcl-1 inhibitor 18 | ||
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V51321 | Mcl-1 inhibitor 6 | 2598978-56-2 | myeloid cell leukemia 1 (Mcl-1) inhibitor |
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V51645 | MCL-1/BCL-2-IN-2 | 2163793-44-8 | MCL-1/BCL-2-IN-2 (Compound 6) is a potent and specific inhibitor of Mcl-1 and Bcl-2. |
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V14901 | Mcl1-IN-2 | 292057-76-2 | IMB-XH1 is a myeloid cytokine 1 (Mcl-1) inhibitor. |
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V0003 | Navitoclax (ABT-263) | 923564-51-6 | Navitoclax (formerly ABT-263) is a novel, highly potent,orally bioavailable small-molecule inhibitor of the BCL (B-cell leukemia) protein family such as Bcl-xL, Bcl-2 and Bcl-w with Ki of ~ 0.5 nM, ~1 nM and ~1 nM in cell-free assays. |
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V0004 | Obatoclax Mesylate (GX15-070) | 803712-79-0 | Obatoclax Mesylate (also known as GX15 070), the mesylate salt of obatoclax, is a potent inhibitor of Bcl-2 (B-cell leukemia protein-2) protein with a Ki of 0.22 μM in a cell-free assay. |
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V80227 | Oblimersen sodium | Oblimersen sodium is an inhibitor (blocker/antagonist) of BCL-2 RNA. | |
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V76580 | PUMA BH3 | PUMA BH3 is a p53 positive regulator of apoptosis (PUMA) BH3 domain-containing polypeptide, which works as a direct activator of Bak with a Kd of 26 nM. | |
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V81255 | PUMA BH3 TFA | PUMA BH3 TFA is a p53 positive regulator of apoptosis (PUMA) BH3 domain-containing polypeptide, which works as a direct activator of Bak with a Kd of 26 nM. | |
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V7551 | Pyridoclax (MR29072) | 1651890-44-6 | Pyridoclax, formerly known as MR29072, is a potent and selective Mcl-1 inhibitor. |
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V81269 | r8 Bid BH3 | r8 Bid BH3 is a biologically active peptide. | |
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V81325 | Rosomidnar sodium (PNT100 sodium) | PNT100 sodium is an unmodified DNA oligonucleotide sequence that is complementary to the upstream regulatory region of the BCL-2 gene, inhibiting tumor cell proliferation/growth and inducing cell death. | |
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V85955 | S1g-10 | 3032432-71-3 | |
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V4116 | S55746 | 1448584-12-0 | S55746 (formerly known as S-055746 and BCL201) is a novel, potent, selective and orally bioactiveBCL-2 inhibitor with Ki of 1.3 nM. |
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V2797 | S63845 | 1799633-27-4 | S63845 is a potent, selective and high affinity small molecule inhibitor of MCL1 (myeloid cell leukemia 1) with Ki value < 1.2 nM. |
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V2800 | S63845 TFA | 1799633-27-4 | S63845 TFA, the Trifluoroacetic acid salt of S63845, is a potent, selective small molecule inhibitor of MCL1 (myeloid cell leukemia 1) with Ki value < 1.2 nM. |
|
V5242 | S64315 (MIK665) | 1799631-75-6 | MIK665 (also known asMIK-665; S-64315) is a novel, investigational and specific Mcl-1 inhibitor with an IC50of 1.81 nM. |
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V0008 | sabutoclax (BI 97C1) | 1228108-65-3 | Sabutoclax (BI-97C1),a derivative of apogossypolone, is a novel and potent pan-Bcl-2 inhibitor with IC50 of 0.31 μM, 0.32 μM, 0.20 μM and 0.62 μM forBcl-xL, Bcl-2, Mcl-1 and Bfl-1, respectively. |
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V15950 | TCPOBOP | 76150-91-9 | TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver damage or tissue loss. |
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