Src

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Src

Src, Yes, Fyn, and Fgr make up the SrcA subfamily, while Lck, Hck, Blk, and Lyn belong to the SrcB subfamily, and Frk has its own subfamily. The Src family kinase (SFK) family of non-receptor tyrosine kinases has nine members in total. Src-family kinases (SFKs) have been identified as important immune cell regulators of numerous intracellular signaling pathways.Src-family kinases (SFKs) participate in a number of signaling transduction cascades, including those originating from integrins, growth factor receptors, T and B cell antigen receptors, and Fc receptors. Src-family kinases (SFKs) can play both positive and negative regulatory roles in cellular signaling.By phosphorylating immunoreceptor tyrosine-based inhibitory motifs (ITIMs) on inhibitory receptors, they can attract and activate inhibitory molecules like the phosphatases SHP-1 and SH2 containing 5′ inositol phosphatase (SHIP-1) and act as negative regulators of cellular signaling.

Src related products

Cat No.	Product Name	CAS No.	Product Description
V88068	(R)-LW-Srci-8		(R)-LW-Srci-8 is a selective covalent inhibitor of c-Src (IC50= 35.83 nM), which can impair the autophosphorylation of c-Src by targeting the autophosphorylation site (Y419) of c-Src kinase.
V119770	AG01		AG01 is a monoclonal antibody targeting the granule protein precursor (GP88).
V88070	Cisplatin/Dasatinib prodrug-1		Cisplatin/Dasatinib prodrug-1 (Compound 3) is a prodrug of Cisplatin and Dasatinib.
V88069	CSK substrate		CSK substrate is a specific substrate of C-terminal Src kinase (CSK), which can bind to CSK and downregulate the levels of Src family members.
V108919	DFCI-002-06	3092208-36-8	DFCI-002-06 is an orally effective dual-target HCK/BTK protein degrader with DC₅₀ values of 1.3 nM for HCK and 4.5 nM for BTK.
V97116	FAK inhibitor 7	2890814-94-3	FAK inhibitor 7 is a FAK inhibitor with IC50 of 3.58 nM.
V113526	FITC-amide-C2 Lck inhibitor 2	1338346-32-9	FITC-amide-C2 Lck inhibitor 2 is a FITC-labeled Lck inhibitor.
V119000	FRK Recombinant Human Active Protein Kinase		FRK recombinant human active protein kinase is a non-receptor tyrosine kinase belonging to the Fyn-associated kinase family and is a member of the BRK kinase family (BFK).
V118909	FYN Y531F Recombinant Human Active Protein Kinase		FYN Y531F recombinant human active protein kinase is an oncogene that directly activates YANK2 by phosphorylation of the Y110 site.
V109918	Fyn-IN-1	3107638-80-9	Fyn-IN-1 (compound 43) is a selective blood-brain barrier penetration inhibitor that inhibits Fyn and GSK-3β, with IC50 values of 0.044 μM and 0.61 μM, respectively.
V116671	Hck-IN-3		Hck-IN-3 (compound 2D) is an orally effective HCK inhibitor (KD = 3.92 μM).
V107826	ISO24	473707-40-3	ISO24 (compound 4a) is a potent ligand for Src SH2 with an IC50 of 4.4 mM in BIAcore analysis.
V87990	KIN-8194	330786-01-1	KIN-8194 is an orally active dual inhibitor of HCK and BTK with IC50 values of 0.915 and 0.495 nM, respectively.
V109967	LCK degrader-3	3095032-59-7	LCK Degrader-3 (Compound 20) is a CRBN-based LCK molecular glue degrader.
V83632	Lck-IN-2	2615173-24-3
V117716	Lck-IN-4	1326278-38-9	Lck-IN-4 (compound A-1) is a protein tyrosine kinase Lck inhibitor with an IC50 value of 2 nM.
V109920	Lck-IN-5	1356734-45-6	Lck-IN-5 (e.g., C10) is a potent and selective inhibitor of lymphocyte-specific protein tyrosine kinases (LCK).
V117028	Papaveroline	574-77-6	Papaverine is an inhibitor of Fyn tyrosine kinase.
V88074	pFYN peptide		pFYN peptide is a biotinylated, phosphorylated peptide substrate derived from FYN (Src family kinase).
V0668	PP1	172889-26-8	PP1 (known also as EI275; EI-275; PP-1; PP 1; AG1872; AG-1872) is a novel, potent and selective Src kinase inhibitor with potential antitumor activity.