FAK

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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FAK

FAK (Focal Adhesion Kinase, or PTK2) is a protein tyrosine kinase that is not associated with receptors and is not located on membranes. It is activated at the sites of integrin clustering and cell-matrix adhesions by autophosphorylation (at Tyr397), Src, and other tyrosine kinases. By transferring signals governing cell migration, adhesion, and survival from the extracellular matrix to the cytoplasm, FAK mediates integrin-based cell signaling.
Many tumors, including those from the head and neck, colon, breast, prostate, liver, and thyroid, overexpress FAK. Additionally, in these tumors, FAK overexpression is strongly associated with an invasive phenotype. Glioblastomas and ovarian cancer cells are less likely to invade when dominant-negative FAK fragments are overexpressed and FAK signaling is inhibited. FAK is a crucial target for the creation of anti-metastatic and anti-neoplastic medications.

FAK related products

Cat No.	Product Name	CAS No.	Product Description
V128262	Active focal adhesion kinase, Human		Active focal adhesion kinase, human, is a cytosolic protein tyrosine kinase that is concentrated in adhesion focals formed between cells growing in the presence of extracellular matrix components.
V96767	Adhesamine diTFA	1201698-09-0	Adhesamine diTFA is a dumbbell-shaped molecule that activates the MAPK/FAK pathway.
V88027	Antitumor agent-165		Antitumor agent-165 (Compound 10l) is a potent inhibitor of focal adhesion kinase (FAK).
V115031	BI-0319	2341740-85-8	BI-0319 is a selective PTK2/FAK PROTAC degrader.
V112492	BSJ-04-146	2414478-45-6	BSJ-04-146 is a highly potent and selective PROTAC-targeting focal adhesion kinase (FAK) inhibitor (IC50 = 26 nM).
V102536	Conteltinib tetrahydrochloride		Continib tetrahydrochloride (CT-707 tetrahydrochloride) is the tetrahydrochloride form of continib.
V118961	FAK aa411-686 Recombinant Human Active Protein Kinase		Focal adhesion kinase (FAK) is a cytoplasmic non-receptor tyrosine kinase that can bind to integrins and growth factor receptors to regulate cell adhesion, proliferation, migration, invasion and metastasis.
V135536	FAK activator-1	2769848-56-6	FAK activator-1 is a FAK activator and mucosal healing inducer.
V112018	FAK ligand-2	2414478-49-0	FAK ligand-2 is a FAK inhibitor and a ligand for the target protein of PROTAC (FAK).
V117008	FAK ligand-5	1227948-58-4	FAK ligand-5 is a FAK ligand.
V135537	FAK-IN-18	2941086-18-4	FAK-IN-18 is a focal adhesion kinase (FAK) inhibitor with an IC50 of 0.84 nM.
V93188	FAK-IN-21	2919213-32-2	FAK-IN-21 (Compound 9) is a FAK inhibitor with IC50 of 37.52 nM.
V105287	FAK-IN-23	2491708-73-5	FAK-IN-23 (Compound II) is an inhibitor of focal adhesion kinase (FAK).
V135538	FAK-IN-24	3062175-62-3	FAK-IN-24 is a FAK inhibitor (IC50: 0.815 nM).
V135539	FAK-IN-25		FAK-IN-25 is a FAK inhibitor with an IC50 value of 50.98 nM.
V135540	FAK-IN-26	2801785-12-4	FAK-IN-26 is a focal adhesion kinase (FAK) inhibitor that can cross the blood-brain barrier (IC50: 0.87 nM).
V135541	FAK-IN-27		FAK-IN-27 is a highly effective and selective FAK inhibitor with an IC50 value of 4.968 nM.
V110935	FAK-IN-29	3104566-26-6	FAK-IN-29 is a selective FAK inhibitor with an IC50 value of 0.5 nM.
V115690	GZD-257		GZD-257 is an ATP-competitive FAK inhibitor that can cross the blood-brain barrier (IC50 = 14.3 nM), and its selectivity for FAK is 4.77 times higher than its selectivity for Pyk2 (IC50 = 68.2 nM).
V102803	Ifebemtinib hydrochloride		Ifebemtinib (BI-853520) hydrochloride is an orally active and potent focal adhesion kinase (FAK) inhibitor (recombinant FAK IC50=1 nM).