TGF-β Receptor

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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TGF-β Receptor

Single pass serine/threonine kinase receptors are TGF-Rs, or transforming growth factor receptors. Transforming growth factor beta (TGF-beta) is a pleiotropic cytokine that participates in a wide range of biological functions, including the regulation of growth, differentiation, migration, cell survival, adhesion, and the specification of developmental fate, in both healthy and pathological conditions. Members of the TGF-beta superfamily communicate via a receptor complex made up of type II and type I receptors, both of which are serine/threonine kinases.At the center of the signaling cascade, the type I receptors, also known as activin receptor-like kinases (ALK), transmit TGF-beta signals to Smad proteins, which are intracellular transcriptional regulators.
ALKs have extracellular binding domains, transmembrane domains, GS domains that type II receptors use to activate them, and kinase domains that trigger the activation of subsequent signaling molecules. ALKs mediate the effect of TGF-beta superfamily on a variety of cellular processes such as proliferation, differentiation, apoptosis, adhesion and migration, and therefore play important roles in many biological processes. ALKs may make good drug targets because they have been linked to a variety of diseases, including tumorigenesis and immune disorders.

TGF-β Receptor related products

Cat No.	Product Name	CAS No.	Product Description
V84595	Itacnosertib (hydrocholide) (TP-0184 (hydrocholide))	2409543-84-4
V22771	ITD-1	1099644-42-4	ITD-1 is a selective inhibitor of TGF-β signaling (IC50 = 0.85 μM); exhibits little or no inhibition of activin, Wnt or BMP signaling pathways.
V87102	J-1149	2883580-95-6	J-1149 is a potent ALK5 inhibitor with an IC50 value of 0.017 μM.
V106344	KQFK	162290-88-2	KQFK is an inactive control for KRFK, a TSP-1-derived peptide that activates TGF-β.
V67578	KRFK	162290-78-0	KRFK is a bioactive peptide extracted from TSP-1 and can activate TGF-β.
V76847	KRFK TFA		KRFK TFA is a bioactive peptide extracted from TSP-1 and can activate TGF-β.
V67567	LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA) (LSKL, Inhibitor of Thrombospondin (TSP-1) trifluoroacetate)	2828433-17-4	LSKL, Inhibitor of Thrombospondin (TSP-1) TFA is a tetrapeptide extracted from LAP-TGFβ and is a competitive TGF-β1 antagonist.
V31090	LSKL, Inhibitor of Thrombospondin TSP-1	283609-79-0	LSKL is a potent and peptide-based inhibitor of Thrombospondin TSP-1 with the potential to be used for treatinghypertrophic scar.
V3756	LY3200882	1898283-02-7	LY3200882 is a next generation,ATP competitive, potent, highly selective small molecule inhibitor of TGF-β receptor type 1 (TGFβRI).
V98117	LY550410	737791-20-7	LY550410 is a small molecule ATP-competitive type I TGF-β receptor kinase inhibitor with a heteroaromatic ring that effectively binds to the active site of the kinase domain.
V84758	M4K2163 dihydrochloride	2863635-04-3
V88161	M4K2281		M4K2281 is a selective inhibitor of activin receptor-like kinase 2 (ALK2) with IC50 of 2 nM.
V88166	M4K2306	3034840-25-7	M4K2306 is a selective inhibitor of activin receptor-like kinase 2 (ALK2) with IC50 of 7 nM.
V67584	Maohuoside A	128988-55-6	Maohuoside A, a single compound extracted from E.
V78829	MU1700		MU1700 is an orally bioactive, potent ALK1/2 inhibitor (antagonist) with IC50s of 13 nM and 6 nM, respectively, which is cell membrane permeable (penetrable) and has high brain permeability.
V84564	OXA-06 hydrochloride	1825455-91-1
V67586	Pentabromopseudilin	10245-81-5	Pentabromopseudilin (PBrP) is a marine antibiotic extracted from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus.
V86176	PKA Substrate	121932-31-8
V67585	Ramatercept	1169766-01-1	Ramatercept is a soluble ActRIIB receptor that works as a soluble activin receptor 2 (ACVR2) antagonist.
V37829	BMP signaling agonist sb4	100874-08-6	BMP signaling agonist sb4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with EC50 of 74 nM and activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9.