TGF-beta(Smad)

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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TGF-beta(Smad)

The pleiotropic protein known as transforming growth factor-beta (TGF-) is a member of a superfamily that controls several cellular processes, including growth, development, and differentiation. The Smad proteins, which are the intracellular TGF-beta signaling effectors, are activated by receptors and move into the nucleus where they control transcription. Although this pathway is fundamentally straightforward, cooperation with sequence-specific transcription factors, combinatorial interactions in the heteromeric receptor and Smad complexes, receptor-interacting and Smad-interacting proteins, and other factors enable significant versatility and diversity of TGF-beta family responses. Smad activation and function are further regulated by other signaling pathways.
Additionally, TGF-beta receptors activate Smad-independent pathways that enable Smad-independent TGF-beta responses in addition to regulating Smad signaling. Abnormal TGF- signaling has been linked to a number of illnesses, including cancer, cardiovascular disease, and fibrosis. Consequently, it is acknowledged that the TGF-signaling pathway is a potential drug target.

TGF-beta(Smad) related products

Cat No.	Product Name	CAS No.	Product Description
V4080	SRI-011381	1629138-41-5	SRI-011381 (SRI011381) is a novel and potent agonist of the TGF-beta signaling pathway with the potential for treatment of Alzheimers disease.
V67545	SRI-011381 hydrochloride	2070014-88-7	SRI-011381 HCl is an orally bioavailable activator of the TGF-β signaling pathway with neuro-protective (neuro-protection) effects.
V3718	TP0427736	864374-00-5	TP0427736 is a novel, potent and selective inhibitor ofALK5 kinase with IC50 value of 2.72 nM andappropriate in vitro and in vivo profiles.
V67557	Trabedersen (AP 12009)	925681-61-4	Trabedersen (AP 12009) is an antisense oligodeoxynucleotide that specifically inhibits TGF-beta2 (TGF-beta/Smad).